INTRAVASCULAR DELIVERY SYSTEM FOR THERAPEUTIC AGENTS

• US 20090048583A1
• Filed: 10/14/2008
• Published: 02/19/2009
• Est. Priority Date: 02/10/2004
• Status: Abandoned Application

• Current Assignee: Kevin Holbrook, Michael S. Williams, Terrance Ransbury
• Original Assignee: Kevin Holbrook, Michael S. Williams, Terrance Ransbury
• Inventors: Holbrook, Kevin, Williams, Michael S., Ransbury, Terrance
• Application Number:
  US12/251,216
• Publication Number:
  US 20090048583A1
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/14232 Roller pumps
• CPC Class Codes: A61M 5/14236 Screw, impeller or centrifugal type pumps
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence

Abstract

Described herein is a system for intravascular drug delivery system, which includes a reservoir implantable a blood vessel, an intravascular pump fluidly coupled to the reservoir and an anchor expandable into contact with a wall of the blood vessel to retain the system within the vasculature. Delivery conduits may be extend from the reservoir and are positionable at select locations within the vasculature for target drug delivery to select organs or tissues.

Claims

1. A system for intravascular drug delivery, the system comprising:

a reservoir proportioned for implantation within a blood vessel;

a flexible elongate device body proportioned for implantation within the blood vessel;

an anchor coupled to the device body and expandable into contact with a wall of the blood vessel;

a pump housed within the device body and fluidly coupled to the reservoir, the pump operable to direct agent from the reservoir into the bloodstream.

2. The system according to claim 1, wherein the reservoir is housed within the device body.

3. The system according to claim 2, wherein the reservoir comprises an inflatable bladder disposed within the device body.

4. The system according to claim 1, wherein the reservoir is external to the device body.

5. The system according to claim 4, wherein the reservoir comprises an elongate inflatable bladder extending longitudinally from the device body.

6. The system according to claim 1, wherein the pump includes a motor and an energy source electrically coupled to the motor.

7. The system according to claim 5, wherein the energy source includes a battery.

8. The system according to claim 1, wherein the reservoir extends longitudinally from the device body.

9. The system according to claim 1, wherein the device body includes at least one flexible region, the region sufficiently flexible to permit bending of the device body during movement of the device through a blood vessel.

10. The system of claim 9, wherein the device body includes a plurality of housing segments, and flexible regions interconnecting adjacent housing segments.

11. The system of claim 10, wherein the pump is sealed within one of the housing segments, and wherein the system further includes a motor and a battery each sealed within housing segments.

12. The system of claim 10, wherein the reservoir is positioned within a plurality of the housing segments.

14. The system of claim 1, wherein the device body is formed of titanium.

15. The system of claim 1, wherein the device body has a length of approximately 10 cm or greater.

16. The system of claim 1, wherein the device body has a cross-sectional area of approximately 79 mm² or less.

17. The system of claim 16, wherein the pulse generator has a cross-sectional area of approximately 40 mm² or less.

18. The system of claim 1, wherein the pump is selected from the group of pumps consisting of gear pumps, peristaltic pumps, solenoid pumps, vacuum pumps, venturi pumps, double-acting membrane pumps, metering pumps, syringe pumps and vaporization displacement pumps.

19. The system according to claim 1, wherein the reservoir contains microspheres containing an agent.

20. The system of claim 1, further including telemetry circuitry within the device housing and a remote communication device operable from outside the body to communicate with the telemetry circuitry.

21. The system according to claim 1, further including at least one elongate conduit extending from the device body, wherein the pump is operable to direct agent through the conduit into the bloodstream.

22. The system according to claim 21, further including an anchor expandable to anchor the elongate conduit within a blood vessel.

23. The system according to claim 21, wherein the device body is positionable in a first blood vessel and the conduit is positionable in a second, different, blood vessel.

24. The system according to claim 1, wherein the system includes a fill conduit extending from the reservoir, a fill port coupled to the fill conduit, and an extracorporeal reservoir connectable to the fill conduit.

25. The system according to claim 24, wherein the fill port is positionable within a blood vessel.

26. The system according to claim 24, wherein the fill port is positionable within a subcutaneous pocket.

27. The system according to claim 24, wherein the extracorporeal reservoir comprises a syringe.

28. The system according to claim 24, wherein the syringe includes a needle engageable with the fill port.

29. The system according to claim 1, wherein:

the reservoir includes a mixing chamber, a first chamber containing a first substance, and a second chamber containing a second substance;

the pump is a dispensing pump positioned to pump agent from the mixing chamber into the bloodstream;

the system further includes a first pump for pumping the first substance from the first chamber into the mixing chamber;

the system further includes a second pump for pumping the second substance from the second chamber into the mixing chamber.

30. The system according to claim 29, wherein the first substance is a liquid and the second substance is a powder.

31. The system according to claim 30, wherein the second pump is a metering pump.

32. The system according to claim 30, wherein the first chamber is an inflatable bladder.

33. The system according to claim 32, wherein the inflatable bladder is positioned external to the device body, and wherein the second chamber is positioned within the device body.

34. The system according to claim 1, further including:

a controller within the device body, wherein the pump is controlled by the controller to pump agent into the bloodstream.

35. The system according to claim 34, wherein the controller is programmed to cause agent delivery according to a predetermined dosing schedule.

36. The system according to claim 34, further including a sensor on the device body for detecting a condition within the patient'"'"'s body, wherein the controller is responsive to a condition detected by the sensor to cause agent to be pumped into the bloodstream.

37. The system according to claim 36, wherein the controller is responsive to a degree of the condition detected by the sensor to determine a dosage of agent to be pumped into the bloodstream.

38. The system according to claim 34, wherein the controller includes telemetry circuitry and the system includes a remote communication device operable from outside the body to communicate with the telemetry circuitry, wherein the controller is responsive to signals received by the telemetry circuitry to cause agent to be pumped into the bloodstream according to a specified dosing schedule.

13. The system of claim 13, wherein the reservoir includes a plurality of bladders, each positioned in a corresponding one of the housing segments.

39-68. -68. (canceled)