SYSTEM AND METHOD FOR SPECTROSCOPIC PHOTOACOUSTIC TOMOGRAPHY
First Claim
1. A system for spectroscopic photoacoustic tomography of a sample, the system comprising:
- at least one light source configured to deliver light pulses at two or more different wavelengths to the sample;
an ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample; and
a control system in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals wherein, upon application of light pulses of two or more different wavelengths to the sample, the control system is configured to determine the local spectroscopic absorption of substances at any location in the sample.
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Accused Products
Abstract
A system and method for spectroscopic photoacoustic tomography of a sample include at least one light source configured to deliver light pulses at two or more different wavelengths to the sample. An ultrasonic transducer is disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample. A control system is provided in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals, wherein upon application of light pulses of two or more different wavelengths to the sample, the control system is configured to determine the local spectroscopic absorption of substances at any location in the sample. The system may further provide for one or more of ultrasound imaging. Doppler ultrasound imaging, and diffuse optical imaging of the sample.
155 Citations
24 Claims
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1. A system for spectroscopic photoacoustic tomography of a sample, the system comprising:
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at least one light source configured to deliver light pulses at two or more different wavelengths to the sample; an ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample; and a control system in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals wherein, upon application of light pulses of two or more different wavelengths to the sample, the control system is configured to determine the local spectroscopic absorption of substances at any location in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for spectroscopic photoacoustic tomography of a sample, comprising;
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providing at least one light source; delivering light pulses at two or more different wavelengths to the sample; receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample with an ultrasonic transducer; reconstructing photoacoustic tomographic images from the received photoacoustic signals; and determining the local spectroscopic absorption of substances at any location in the sample. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A multi-modality imaging system, comprising:
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a light source having a tunable wavelength, the light source configured to deliver light pulses at two or more different wavelengths to a sample; an ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample and for transmitting ultrasound signals to the sample; an optical detector adjacent to the sample for detecting light scattered upon delivery of the light pulses to the sample; and a control system in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals and for generating at least one of ultrasound images and Doppler ultrasound images, and in communication with the optical detector for providing diffuse optical imaging of the sample, wherein upon application of light pulses of two or more different wavelengths to the sample, the control system is configured to determine the local spectroscopic absorption of substances at any location in the sample.
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Specification