Estriol Therapy for Autoimmune and Neurodegenerative Diseases and Disorders
First Claim
1. A method of treating a patient exhibiting at least on clinical symptom of a neurodegenerative disease comprising administering at least one primary agent being an estrogen or estrogen receptor active agent at a therapeutically effective dosage in an effective dosage form to a patient in order to prevent or treat a neurodegenerative disease.
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Abstract
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, neurodegenerative diseases or disorders, such as Alzheimer'"'"'s disease, Parkinson'"'"'s Disease, multiple sclerosis, stroke, ALS Pick'"'"'s disease, prion disease and Huntington'"'"'s disease. Most preferably the invention uses estrogens, estranges, estriol or estrogen receptor active agents to prevent or ameliorate clinical symptoms of the diseases and disorders.
56 Citations
23 Claims
- 1. A method of treating a patient exhibiting at least on clinical symptom of a neurodegenerative disease comprising administering at least one primary agent being an estrogen or estrogen receptor active agent at a therapeutically effective dosage in an effective dosage form to a patient in order to prevent or treat a neurodegenerative disease.
- 13. A method of preventing or treating a patient exhibiting at least one clinical symptom of a neurodegenerative disease or disorder comprising administering 8 milligrams of estriol orally each 24 hours to ameliorate the symptoms of the disease or disorder.
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18. A method of treating a patient exhibiting at least one symptom of a neurodegenerative disease or disorder to ameliorate at least on symptom of that disease or disorder comprising administering estriol at a dose of about 4 to about 16 milligrams of estriol each 24 hours;
- and progesterone at a dose of about 100 to about 200 milligrams per 24 hours.
- View Dependent Claims (22)
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19. A method of treating a patient exhibiting at least one clinical symptoms of neurodegeneration to ameliorate the disease comprising administering estriol at a dose of about 4 to about 16 milligrams of estriol each 24 hours;
- and a glucocorticoid.
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20. A method of treating a patient to prevent or ameliorate the symptoms of the neurodegenerative disease or disorder comprising administering an estrogen receptor beta agonist at a therapeutically effective dosage in an effective dosage form.
Specification