IMPLANTABLE DEVICES FOR FIBER OPTIC BASED DETECTION OF NOSOCOMIAL INFECTION

• US 20090155770A1
• Filed: 12/12/2007
• Published: 06/18/2009
• Est. Priority Date: 12/12/2007
• Status: Abandoned Application

• Current Assignee: Avent Incorporated (Avanos Medical, Inc.)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Atta-Mensah, Akosua, Brown, Tameka, Shultz, Tod Hoover, Presley, Talbot, Feaster, Shawn R., Phillips, Erica M., Rainone, Mike, Baird, Daniel, Plowman, Thomas Edward, Hantke, Richard
• Application Number:
  US11/954,881
• Publication Number:
  US 20090155770A1
• Time in Patent Office: Days
• US Class Current: 435/5
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: G01N 2021/6439 with indicators, stains, dyes, tags, labels, marks
• CPC Class Codes: G01N 2021/6484 Optical fibres
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence
• CPC Class Codes: G01N 2201/0221 Portable; cableless; compact; hand-held
• CPC Class Codes: G01N 2201/129 Using chemometrical methods

Abstract

Disclosed are methods and devices for continuous in vivo monitoring of a potential infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of a hospital acquired infection, thereby providing for earlier intervention and improved recovery rates from bacterial infection. Disclosed methods utilize implantable devices for location at an in vivo site. The implantable device is held in conjunction with an optical fiber that detects and transmits an optically detectable signal generated in the presence of a pathogen. Upon generation of the emission, the optically detectable emission signal may be transmitted to a portable detection/analysis device. Analysis of the characteristics of the emission signal produced may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel, for instance via a wireless transmission system.

Claims

1. A method for detecting the presence or amount of a pathogen that is a source of a hospital acquired infection comprising:

locating a portion of an implantable device in an in vivo environment;

transmitting an optically detectable signal that is directly or indirectly emitted from the pathogen through a fiber optic cable to a detector, wherein the fiber optic cable is held in conjunction with the implantable device; and

determining the presence or amount of the pathogen in the environment.

2. The method according to claim 1, further comprising transmitting an excitation signal to the pathogen.

3. The method according to claim 1, wherein the optically detectable emission signal is an autofluorescent emission of the pathogen.

4. The method according to claim 1, wherein the implantable device comprises a catheter.

5. The method according to claim 4, further comprising transporting a fluid through the catheter from the in vivo environment to a reservoir, wherein the fluid includes the pathogen.

6. The method according to claim 5, wherein the optically detectable emission signal is emitted from the pathogen in the reservoir.

7. The method according to claim 5, further comprising concentrating the proportion of the pathogen in the fluid.

8. The method according to claim 4, further comprising transporting a fluid through the catheter to the in vivo environment.

9. The method according to claim 1, wherein the in vivo environment is a surgical site.

10. A device for detecting the presence or amount of a pathogen that is a source of a hospital acquired infection comprising:

an implantable device;

a fiber optic cable affixed to the implantable device, the fiber optic cable comprising a first end for location in an environment containing the pathogen and a second end in optical communication with an optical detector;

a portable enclosure containing a power source, the optical detector, a signal processor, and a signaling device for emitting a signal upon detection of the presence or amount of the pathogen in the environment; and

a connecting device for attaching the enclosure to the clothing or body of a wearer.

11. The device of claim 10, the enclosure further including a transmitter for transmitting a signal containing information regarding the presence or amount of the bacteria in the environment to a receiver.

12. The device of claim 11, wherein the transmitter is a wireless transmitter.

13. The device of claim 10, the enclosure further containing an excitation energy source for providing an excitation signal to the environment.

14. The device of claim 10, the fiber optic cable comprising a first optical fiber in optical communication with the excitation energy source, and a second optical fiber in optical communication with the optical detector.

15. The device of claim 10, wherein the connecting device is for connecting the enclosure to a piece of clothing.

16. The device of claim 10, wherein the connecting device is for connecting the enclosure to a wearer'"'"'s skin.

17. The device of claim 10, wherein the implantable medical device comprises a catheter.

18. The device of claim 17, wherein the catheter is a pain release catheter.

19. The device of claim 18, wherein the catheter is a drainage tube.

20. The device of claim 18, wherein the catheter is a venous catheter.

21. The device of claim 10, wherein the implantable medical device is an endotracheal tube.

22. The device of claim 10, wherein a portion of the fiber optic cable is held within a wall of the implantable device.

23. The device of claim 10, wherein the implantable device is a multi-lumen device.

24. The device of claim 23, wherein a portion of the fiber optic cable is held within a lumen of the implantable device.