Methods and compositions for treating diseases and conditions associated with mitochondrial function
First Claim
1. A method of treating a disorder comprising inhibiting the activity of ATP synthase complexes in cells affected by said disorder through exposing said affected cells to a composition able to bind the oligomycin sensitivity conferring protein of said ATP synthase complexes, wherein said disorder is selected from the group consisting of a bacterial infection, a viral infection, a fungal infection, a parastitic infection, a disorder involving aberrant angiogenesis, a disorder involving aberrant blood pressure regulation, and a disorder involving aberrant HDL/LDL regulation.
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Abstract
The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase associated disorders, and the like.
38 Citations
18 Claims
- 1. A method of treating a disorder comprising inhibiting the activity of ATP synthase complexes in cells affected by said disorder through exposing said affected cells to a composition able to bind the oligomycin sensitivity conferring protein of said ATP synthase complexes, wherein said disorder is selected from the group consisting of a bacterial infection, a viral infection, a fungal infection, a parastitic infection, a disorder involving aberrant angiogenesis, a disorder involving aberrant blood pressure regulation, and a disorder involving aberrant HDL/LDL regulation.
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18. A composition comprising a compound able to bind the oligomycin sensitivity conferring protein of a F1F0 ATPase, wherein said compound is selected from the group consisting of:
Specification