Method of Providing Magnetised Particles at a Location

• US 20090306455A1
• Filed: 06/14/2006
• Published: 12/10/2009
• Est. Priority Date: 06/17/2005
• Status: Abandoned Application

• Current Assignee: Oxford Instruments Molecular Biotools Ltd. (Oxford Instruments PLC), UCB Pharma SA (UCB SA), University of Durham
• Original Assignee: Oxford Instruments Molecular Biotools Ltd. (Oxford Instruments PLC), UCB Pharma SA (UCB SA), University of Durham
• Inventors: Cowburn, Russell Paul, Eaton, Michael, Evans, John Simon Owen, Parker, David, Slade, Robert Andrew
• Application Number:
  US11/922,021
• Publication Number:
  US 20090306455A1
• Time in Patent Office: Days
• US Class Current: 600/12
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A method of providing magnetised particles at a location using particles which can be switched between magnetic and non-magnetic states by exposure to a suitable magnetic field. The method comprises conveying the particles in their non-magnetic state to the location; and then exposing the particles to the suitable magnetic field so that they switch to their magnetic state.

Claims

1. :

A method of providing magnetized particles at a location using particles which can be switched between magnetic and non-magnetic states by exposure to a suitable magnetic field, the method comprising;

conveying the particles in their non-magnetic state to the location; and

exposing the particles to the suitable magnetic field so that they switch to their magnetic state.

2. :

A method according to claim 1, wherein the particles exhibit a flux closing micromagnetic configuration in their non-magnetic state.

3. :

A method according to claim 1, wherein the particles comprise nano particles.

4. :

A method according to claim 1, wherein the thickness of the particles is about 5 nm.

5. :

A method according to claim 1, wherein the diameter of the particles is in the range 50-200 nm.

6. :

A method according to claim 1, wherein the particles have anisotropic shapes.

7. :

A method according to claim 1, wherein the thickness of each particle is at least an order of magnitude less than the diameter of the particle.

8. :

A method according to any of the preceding claims claim 1, wherein the suitable magnetic field exposes the particles to a magnetic flux density in the range of 0.01-2 Tesla.

9. :

A method according to claim 1, wherein the step of exposing the particles to the suitable magnetic field comprises moving the location into the magnetic field.

10. :

A method according to claim 1, wherein the step of exposing the particles to the single magnetic field comprises generating a pulsed magnetic field.

11. :

A method according to claim 1, further comprising applying a magnetic field to the particles at the location so as to induce particle motion and thereby disrupt adjacent material at the location.

12. :

A method according to claim 11, wherein the application of the magnetic field to induce particle motion also implements the step of causing the particles to switch to their magnetic state.

13. :

A method according to claim 11, wherein the material is a biological material.

14. :

A method according to claim 11, wherein the material is a cellular or tissue structure.

15. :

A method according to claim 14, wherein the cellular material is a mammalian cell.

16. :

A method according to claim 14, wherein the cellular or tissue structure material is a tumor.

17. :

A method according to any of the preceding lams claim 1, wherein the location is in a body.

18. :

A method according to claim 17, wherein the body is a human or animal body.

19. :

A method according to claim 1, wherein the method is carried out in vitro.

20. :

A method according to claim 1, further comprising exposing the particles in their magnetic state to a sequence of progressively weaker magnetic fields to cause the particles to return to their non-magnetic state.

21. :

A method according to claim 1, wherein the particles are made of Supermalloy (Ni₇₈Fe₁₈Mo₄), Permalloy (Ni₈₀Fe₂₀) or Nickel.

22. :

A method of locally treating a selected biological material in vitro or in vivo, comprising the steps of;

providing anisotropic particles adapted to being switched between magnetic and non-magnetic states;

locating the particles in their nonmagnetic states to a position within the biological material;

providing a magnetic field adapted to exposing the particles to an effective magnetic flux, wherein the magnetic flux causes at least some of the particles to switch to their magnetic states and move;

causing a disruption of some of the biological material adjacent the moving and magnetized particles; and

returning the particles to their nonmagnetic state.

23. :

A method of treatment according to claim 22, wherein the location is in a living human or animal body.

24. :

A method of treatment according to claim 22, wherein the magnetic field comprises a pulsed magnetic field.

25. :

A method of treatment according to claim 22, wherein the effective magnetic flux is in the range of 0.1-0.2 Tesla.