USE OF MULTIPLE CALIBRATION SOLUTIONS WITH AN ANALYTE SENSOR WITH USE IN AN AUTOMATED BLOOD ACCESS SYSTEM
First Claim
1. A method of calibrating an automated analyte measurement system that removes blood from a patient for measurement, comprising passing calibration fluid having at least two different analyte concentrations by an analyte sensor while infusing substantially none of at least one of such calibration fluids into the patient.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to an automated calibration procedure for analyte sensors such as glucose sensors. The system can provide a calibration point at zero analyte concentration as well as a second calibration point at a known analyte concentration or other pre-determined points. Although not restricted to two point calibration procedure, the system as described enables the system to create one or more calibration points. The use of multiple calibration points can allow the system to correct for both slope and bias drifts. The system also provides the opportunity to provide one or more validation samples. The present invention enables a multitude of options in both calibration and validation to ensure effective operation of the system.
121 Citations
21 Claims
- 1. A method of calibrating an automated analyte measurement system that removes blood from a patient for measurement, comprising passing calibration fluid having at least two different analyte concentrations by an analyte sensor while infusing substantially none of at least one of such calibration fluids into the patient.
-
4. An apparatus for the measurement of one or more analytes in blood withdrawn from a patient, comprising:
-
a. A patient connection fluid passage element configured to be placed in fluid communication with the vascular system of a patient; b. An analyte sensor having first and second ports, the first port in fluid communication with the patient connection fluid passage element; c. A first fluid source in fluid communication with the second port of the analyte sensor; d. A second fluid source in fluid communication with the first port of the analyte sensor; e. A first pump mounted with the apparatus so as to move fluid from the first fluid source towards or away from the analyte sensor; f. A second pump mounted with the apparatus so as to urge fluid from the second fluid source toward or away from the analyte sensor; and g. A waste outlet in fluid communication with at least one of the first and second ports of the analyte sensor; h. Wherein at least one of the first fluid source and the second fluid source contains a fluid having a first known analyte concentration suitable for calibration of the analyte sensor. - View Dependent Claims (5, 6, 7, 8, 9, 10, 21)
-
-
11. An apparatus for measurement of one or more analytes in blood withdrawn from a patient, comprising:
-
a. A patient connection fluid passage element configured to be placed in fluid communication with the vascular system of a patient; b. An analyte sensor having first and second ports, the first port in fluid communication with the patient connection fluid passage element and separated therefrom by a fluid passage having a first length; c. A tubing junction comprising first, second, and third ports, the first port in fluid communication with the second port of the analyte sensor and separated therefrom by a fluid passage having a second length; d. A first fluid source in fluid communication with the second port of the tubing junction and separated therefrom by a fluid passage having a third length, where the sum of the second and third lengths is greater than the first length; e. A second fluid source in fluid communication with the third port of the tubing junction; f. A first pump mounted with the apparatus so as to urge fluid from the first fluid source towards or away from the tubing junction; and g. A second pump mounted with the apparatus so as to urge fluid from the second fluid source toward or away from the tubing junction; h. Wherein the first fluid source contains a fluid having a first known analyte concentration suitable for calibration of the analyte sensor. - View Dependent Claims (12, 13, 14, 15, 16)
-
-
17. An apparatus for the measurement of one or more analytes in blood withdrawn from a patient, comprising:
-
a. A patient connection fluid passage element configured to be placed in fluid communication with the vascular system of a patient; b. An analyte sensor having first and second ports, the first port in fluid communication with the patient connection fluid passage element; c. A reservoir in fluid communication with the second port of the analyte sensor; d. A first fluid source in fluid communication with the second port of the analyte sensor, wherein the first fluid source contains a fluid having a first known analyte concentration suitable for calibration of the analyte sensor; e. A first pump mounted with the apparatus so as to urge fluid from the first fluid source towards or away from the analyte sensor; and f. A second pump mounted with the apparatus so as to urge fluid from the reservoir toward or away from the analyte sensor. - View Dependent Claims (18, 19, 20)
-
Specification