OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
First Claim
1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the implantable device comprising:
- a sensing region operatively connected to electronic circuitry configured to generate a signal associated with a concentration of an analyte in a host; and
a membrane located over the sensing region, wherein the membrane comprises a first domain comprising an enzyme configured to react with the analyte and a second domain configured to control a flux of the analyte and oxygen therethrough, and wherein the first domain comprises a first silicone polymer and the second domain comprises a second silicone polymer.
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Abstract
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
201 Citations
16 Claims
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1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the implantable device comprising:
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a sensing region operatively connected to electronic circuitry configured to generate a signal associated with a concentration of an analyte in a host; and a membrane located over the sensing region, wherein the membrane comprises a first domain comprising an enzyme configured to react with the analyte and a second domain configured to control a flux of the analyte and oxygen therethrough, and wherein the first domain comprises a first silicone polymer and the second domain comprises a second silicone polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification