METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION USING RARE CELLS
First Claim
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1. A method for diagnosing, theranosing, or prognosing a condition in a patient comprising:
- detecting a serum marker shed from a primary tumor in a first sample;
enumerating one or more circulating tumor cells in a second sample from said patient; and
diagnosing, prognosing, or theranosing the condition in said patient based on said detecting a serum marker and said enumerating one or more circulating tumor cells.
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Abstract
The invention encompasses methods for diagnosing, theranosing, or prognosing a condition in a patient based on the results of one or more analysis methods. The methods can comprise enriching a sample obtained from the patient for one or more rare cells. The analysis methods can include performing enumeration of the one or more rare cells or cell subtypes, performing nucleic acid analysis, or detecting a serum marker.
80 Citations
37 Claims
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1. A method for diagnosing, theranosing, or prognosing a condition in a patient comprising:
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detecting a serum marker shed from a primary tumor in a first sample; enumerating one or more circulating tumor cells in a second sample from said patient; and diagnosing, prognosing, or theranosing the condition in said patient based on said detecting a serum marker and said enumerating one or more circulating tumor cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for diagnosing, theranosing, or prognosing a condition in a patient comprising:
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performing one or more nucleic acid analysis on a first sample obtained from said patient; enumerating one or more rare cells in a second sample from said patient; and diagnosing, theranosing, or prognosing the condition in said patient based on said enumerating one or more rare cells and said performing one or more nucleic acid analysis. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A method for diagnosing, theranosing, or prognosing a condition in a subject, comprising:
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a) enriching one or more rare cells from a sample obtained from said subject using a microfluidic device; b) performing a first analysis of one or more cell subtypes of said one or more rare cells; and c) evaluating the result of said first analysis to make said diagnosis, theranosis, or prognosis. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for diagnosing, theranosing, or prognosing a condition in a patient comprising:
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enriching one or more CTCs in a sample obtained from said patient; subjecting said one or more CTCs to one or more therapeutic treatments or culturing said one or more circulating tumor cells; and diagnosing, theranosing, or prognosing the condition in the patient. - View Dependent Claims (31, 32, 33, 34, 35)
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36. A business method comprising:
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enriching one or more rare cells in a first sample obtained from a patient using a microfluidic device, wherein the microfluidic comprises an array of obstacles and/or one or more binding moieties; enumerating said one or more rare cells; analyzing a second sample from the patient by performing nucleic acid analysis or detecting a serum marker; diagnosing, theranosing, or prognosing a condition in the patient; and providing a report on said condition in exchange for a fee.
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37. A kit for diagnosing, theranosing, or prognosing a condition in a patient comprising:
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a microfluidic device comprising an array of obstacles and/or one or more binding moieties; and one or more reagents for performing nucleic acid analysis, detecting a serum marker, and/or culturing cells.
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Specification