GANGLIOSIDE BIOSYNTHESIS MODULATORS
First Claim
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1. A process for modifying the cellular population of a ganglioside, the process comprising contacting a cell having at least one ganglioside with an effective amount of a selective late-stage ganglioside biosynthesis inhibitor, the selective ganglioside biosynthesis inhibitor being active in a mammalian cell.
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Abstract
Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation.
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20 Claims
- 1. A process for modifying the cellular population of a ganglioside, the process comprising contacting a cell having at least one ganglioside with an effective amount of a selective late-stage ganglioside biosynthesis inhibitor, the selective ganglioside biosynthesis inhibitor being active in a mammalian cell.
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17. A composition comprising a population of human serum gangliosides, the population comprising less than 34 mol. % α
- 2,8-linked sialic acid containing gangliosides.
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18. A composition comprising a population of human serum gangliosides, the population comprising greater than 3 mol. % O series gangliosides.
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19. A composition comprising a population of human serum gangliosides, the population comprising less than 15 mol. % (β
- 1,3) linked galactose containing gangliosides.
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20. A composition comprising a population of human serum gangliosides, the population comprising less than 23 mol. % of (β
- 1,4) linked GalNac gangliosides.
Specification