OPHTHALMIC COMPOSITION

• US 20100249062A1
• Filed: 09/26/2008
• Published: 09/30/2010
• Est. Priority Date: 09/28/2007
• Status: Abandoned Application

• Current Assignee: Rohto Pharmaceutical Company Limited
• Original Assignee: Rohto Pharmaceutical Company Limited
• Inventors: Fukushima, Kazuhiro, Matsumura, Yasuko
• Application Number:
  US12/680,318
• Publication Number:
  US 20100249062A1
• Time in Patent Office: Days
• US Class Current: 514/57
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 31/721 Dextrans
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/183 Amino acids, e.g. glycine, EDTA or aspartame
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/04 Artificial tears; Irrigation solutions

Abstract

The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) a glucose.

Claims

1. A wetting solution—

eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and

(B) a glucose.

2. The wetting solution—

eye drops for contact lenses according to claim 1, wherein the component (A) is a cellulose-based polymer.

3. The wetting solution—

eye drops for contact lenses according to claim 2, wherein the cellulose-based polymer is one or more member(s) selected from the group consisting of hydroxyethyl cellulose, hydroxypropylmethyl cellulose, and salts thereof.

4. The wetting solution—

eye drops for contact lenses according to any one of claims 1 to 3, which comprises the component (A) in an amount of 0.0001 to 25 (w/v) %.

5. The wetting solution—

eye drops for contact lenses according to claim 1, which comprises the component (B) in an amount of 0.001 to 3 (w/v) %.

6. The wetting solution—

eye drops for contact lenses according to claim 1, which further comprises (C) a nonionic surfactant.

7. The wetting solution—

eye drops for contact lenses according to claim 6, wherein the component (C) is one or more member(s) selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and polyoxyethylene-polyoxypropylene copolymer.

8. The wetting solution—

eye drops for contact lenses according to claim 6, wherein the component (C) is polysorbate 80.

9. The wetting solution—

eye drops for contact lenses according to any one of claims 6 to 8, which comprises the component (C) in an amount of 0.001 to 5 (w/v) %.

10. The wetting solution—

eye drops for contact lenses according to claim 1, wherein the contact lens is a soft contact lens.

11. The wetting solution—

eye drops for contact lenses according to claim 10, wherein the soft contact lens is essentially in soft contact lens Group IV.

12. The wetting solution—

eye drops for contact lenses according to claim 10, wherein the soft contact lens is a soft contact lens made of silicone-hydrogel.

13. The wetting solution—

eye drops for contact lenses according to claim 1, for suppressing eye desiccation or dry eye.