PREDICTION METHOD OF CONCENTRATION FLUCTUATION OF MEASUREMENT TARGET COMPONENTS IN BLOOD USING AREA UNDER BLOOD CONCENTRATION TIME CURVE, AND DEVICE THEREFOR

• US 20100249564A1
• Filed: 03/29/2010
• Published: 09/30/2010
• Est. Priority Date: 03/30/2009
• Status: Abandoned Application

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Okada, Seiki, SATO, Toshiyuki
• Application Number:
  US12/748,990
• Publication Number:
  US 20100249564A1
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

The invention provides A method for predicting a concentration fluctuation of a measurement target component in the blood, comprising steps of: obtaining an initial value of the amount relating to the measurement target component in a subject; obtaining, as a first measurement value, a value of an area under the blood concentration time curve of the measurement target component during a first extraction period; obtaining, as a second measurement value, a value of an area under the blood concentration time curve of the measurement target component during a second extraction period; and predicting the concentration fluctuation of the measurement target component in the blood from the initial value, the first measurement value and the second measurement value, as well as a device for predicting a concentration fluctuation of a measurement target component in the blood.

Claims

1. A method for predicting a concentration fluctuation of a measurement target component in the blood, comprising steps of:

obtaining an initial value of the amount relating to the measurement target component in a subject;

obtaining, as a first measurement value, a value of an area under the blood concentration time curve of the measurement target component, from the amount of the measurement target component contained in a tissue liquid extracted during a first extraction period from a microhole formed on the skin of the subject;

obtaining, as a second measurement value, a value of an area under the blood concentration time curve of the measurement target component, from the amount of the measurement target component contained in a tissue liquid extracted during a second extraction period from the microhole formed on the skin of the subject; and

predicting the concentration fluctuation of the measurement target component in the blood from the initial value, the first measurement value and the second measurement value.

2. The method according to claim 1, wherein the second extraction period is a period after the completion of the first extraction period.

3. The method according to claim 2, wherein the prediction step comprises:

obtaining a first blood concentration of the measurement target component at a first point from the first measurement value;

obtaining a second blood concentration of the measurement target component at a second point from the second measurement value; and

predicting the concentration fluctuation of the measurement target component in the blood from the initial value, the first blood concentration and the second blood concentration.

4. The method according to claim 1, wherein the first extraction period and the second extraction period are started at the same time, and the second extraction period is longer than the first extraction period.

5. The method according to claim 4, wherein the prediction step comprises:

obtaining a first blood concentration of the measurement target component at a first point from the first measurement value;

obtaining a second blood concentration of the measurement target component at a second point from the difference between the second measurement value and the first measurement value; and

predicting the concentration fluctuation of the measurement target component in the blood from the initial value, the first blood concentration and the second blood concentration.

6. The method according to claim 1, wherein the measurement target component is glucose, and the concentration fluctuation of the measurement target component is a fluctuation of a blood glucose value.

7. The method according to claim 6, wherein the fluctuation of a blood sugar value is expressed by each parameter of a prediction of the maximum blood sugar value, a prediction of the time reaching the maximum blood sugar value, and a blood sugar value fluctuation rate.

8. The method according to claim 1, wherein

the first measurement value is a value corrected by a concentration of sodium ion contained in the tissue liquid extracted during the first extraction period, and

the second measurement value is a value corrected by a concentration of sodium ion contained in the tissue liquid extracted during the second extraction period.

9. The method according to claim 1, wherein at least one of the first extraction period and the second extraction period is 60 minutes or more.

10. The method according to claim 1, wherein the sum of the first extraction period and the second extraction period is 120 minutes or more.

11. The method according to claim 1, wherein the second extraction period is 120 minutes or more.

12. The method according to claim 1, wherein the initial value is a blood concentration value of a measurement target component obtained by drawing blood from the subject.

13. A device for predicting a concentration fluctuation of a measurement target component in the blood, comprising:

an input part for inputting an initial value relating to the amount of a measurement target component of a subject;

a first collection member for retaining a tissue liquid extracted during a first extraction period from a microhole formed on the skin of the subject;

a second collection member for retaining a tissue liquid extracted during a second extraction period from the microhole formed on the skin of the subject;

a measurement part for measuring the amount of the measurement target component contained in the first collection member and the amount of the measurement target component contained in the second collection member; and

an analysis part configured for performing operations, comprising;

obtaining, as a first measurement value, a value of an area under the blood concentration time curve of the measurement target component during the first extraction period, from the amount of the measurement target component contained in the first collection member;

obtaining, as a second measurement value, a value of an area under the blood concentration time curve of the measurement target component during the second extraction period, from the amount of the measurement target component contained in the second collection member; and

predicting the concentration fluctuation of the measurement target component in the blood from the initial value, the first measurement value and the second measurement value.

14. The device according to claim 13, wherein the second extraction period is a period after the completion of the first extraction period.

15. The device according to claim 14, wherein the analysis part is configured for performing further operations, comprising:

obtaining a first blood concentration of a measurement target component at a first point from the first measurement value; and

obtaining a second blood concentration of a measurement target component at a second point from the second measurement value;

wherein the concentration fluctuation of the measurement target component in the blood is predicted from the initial value, the first blood concentration and the second blood concentration.

16. The device according to claim 13, wherein the first extraction period and the second extraction period are started at the same time, and the second extraction period is longer than the first extraction period.

17. The device according to claim 16, wherein the analysis part is configured for performing further operations, comprising:

obtaining a first blood concentration of a measurement target component at a first point from the first measurement value; and

obtaining a second blood concentration of a measurement target component at a second point from a value obtained by subtracting the first measurement value from the second measurement value;

wherein the concentration fluctuation of the measurement target component in the blood is predicted from the initial value, the first blood concentration and the second blood concentration.

18. The device according to claim 13, wherein the measurement target component is glucose and the concentration fluctuation of the measurement target component is a fluctuation of blood glucose value.