TISSUE-TREATING IMPLANTABLE COMPOSITIONS
First Claim
1. A method for governing tissue growth, the method comprising providing a substantially planar barrier membrane of resorbable polymer base material having a tissue-growing substantially-smooth side that comprises a tissue-inductive factor and a non-tissue growing substantially-smooth side, the substantially planar barrier membrane of resorbable polymer base material comprising a single layer of resorbable polymer base material between the tissue-growing side and the non-tissue growing side, the single layer of resorbable polymer base material having a substantially uniform composition, wherein a thickness of the single layer of resorbable polymer base material, measured between the tissue-growing side and the non-tissue growing side, is between about 10 microns and about 300 microns, wherein the single layer of resorbable polymer base material is non-porous, wherein the single layer of resorbable polymer base material consists essentially of a material selected from the group consisting of a poly-lactide polymer and a copolymer of two or more cyclic esters, and wherein the single layer of resorbable polymer base material is adapted to maintain a smooth-surfaced barrier between the tissue growing side and the non-tissue growing side, and is adapted to be resorbed into a mammalian body within a period of approximately 18 to 24 months from an initial implantation of the substantially planar barrier membrane of resorbable polymer base material into the mammalian body;
- and forming a spatial barrier with the substantially planar barrier membrane of resorbable polymer base material, the substantially planar barrier membrane of resorbable polymer base material separating a tissue-growth area, which faces the tissue-growing side having the tissue-inductive factor, from a non-tissue-growth area, which faces the non-tissue growing side having a pre-implantation compositional characteristic different from a pre-implantation compositional characteristic of the tissue growing side, wherein the compositional characteristic is defined by an amount or concentration of one or more of a tissue growth inhibitor or anti-tissue agent, an anti-tissue agent or factor, an anti-angiogenic factor, a monoclonal or polyclonal antibody, an antibody fragment, a substance for cellular control, a chemotactic substance for influencing cell-migration, an inhibitory substance for influencing cell-migration, a mitogenic growth factor for influencing cell proliferation, a tissue-inductive factor, a growth factor for influencing cell differentiation, and a factor which promotes angiogenesis.
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Accused Products
Abstract
A prosthesis for repairing a hernia includes an adhesion-resistant biodegradable region and an opposing tissue-ingrowth biodegradable region. When the prosthesis is implanted into the patient, the adhesion-resistant biodegradable region covers a fascial defect of the hernia, and the tissue-ingrowth biodegradable region is located above the adhesion-resistant biodegradable region while being exposed substantially only to the host'"'"'s subcutaneous tissue layer. This orientation allows the tissue-ingrowth biodegradable region to become firmly incorporated with the host'"'"'s body tissue. The adhesion-resistant biodegradable region faces the internal organs and decreases the incidence of adhesions and/or bowel obstruction.
79 Citations
20 Claims
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1. A method for governing tissue growth, the method comprising providing a substantially planar barrier membrane of resorbable polymer base material having a tissue-growing substantially-smooth side that comprises a tissue-inductive factor and a non-tissue growing substantially-smooth side, the substantially planar barrier membrane of resorbable polymer base material comprising a single layer of resorbable polymer base material between the tissue-growing side and the non-tissue growing side, the single layer of resorbable polymer base material having a substantially uniform composition, wherein a thickness of the single layer of resorbable polymer base material, measured between the tissue-growing side and the non-tissue growing side, is between about 10 microns and about 300 microns, wherein the single layer of resorbable polymer base material is non-porous, wherein the single layer of resorbable polymer base material consists essentially of a material selected from the group consisting of a poly-lactide polymer and a copolymer of two or more cyclic esters, and wherein the single layer of resorbable polymer base material is adapted to maintain a smooth-surfaced barrier between the tissue growing side and the non-tissue growing side, and is adapted to be resorbed into a mammalian body within a period of approximately 18 to 24 months from an initial implantation of the substantially planar barrier membrane of resorbable polymer base material into the mammalian body;
- and forming a spatial barrier with the substantially planar barrier membrane of resorbable polymer base material, the substantially planar barrier membrane of resorbable polymer base material separating a tissue-growth area, which faces the tissue-growing side having the tissue-inductive factor, from a non-tissue-growth area, which faces the non-tissue growing side having a pre-implantation compositional characteristic different from a pre-implantation compositional characteristic of the tissue growing side, wherein the compositional characteristic is defined by an amount or concentration of one or more of a tissue growth inhibitor or anti-tissue agent, an anti-tissue agent or factor, an anti-angiogenic factor, a monoclonal or polyclonal antibody, an antibody fragment, a substance for cellular control, a chemotactic substance for influencing cell-migration, an inhibitory substance for influencing cell-migration, a mitogenic growth factor for influencing cell proliferation, a tissue-inductive factor, a growth factor for influencing cell differentiation, and a factor which promotes angiogenesis.
- View Dependent Claims (2, 3, 4, 5, 6, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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7. A method for governing tissue growth, the method comprising providing a substantially planar barrier membrane of resorbable polymer base material having a tissue-growing substantially-smooth side and a non-tissue growing substantially-smooth side, the substantially planar barrier membrane of resorbable polymer base material comprising a single layer of resorbable polymer base material between the tissue-growing side and the non-tissue growing side, the single layer of resorbable polymer base material having a substantially uniform composition, wherein a thickness of the single layer of resorbable polymer base material, measured between the tissue-growing side and the non-tissue growing side, is between about 10 microns and about 300 microns, wherein the single layer of resorbable polymer base material is non-porous, wherein the single layer of resorbable polymer base material consists essentially of a material selected from the group consisting of a poly-lactide polymer and a copolymer of two or more cyclic esters, and wherein the single layer of resorbable polymer base material is adapted to maintain a smooth-surfaced barrier between the tissue growing side and the non-tissue growing side, and is adapted to be resorbed into a mammalian body within a period of approximately 18 to 24 months from an initial implantation of the substantially planar barrier membrane of resorbable polymer base material into the mammalian body;
- and forming a spatial barrier with the substantially planar barrier membrane of resorbable polymer base material, the substantially planar barrier membrane of resorbable polymer base material separating a tissue-growth area, which faces the tissue-growing side having a tissue inductive factor, from a non-tissue-growth area, which faces the non-tissue growing side having a pre-implantation compositional characteristic, which is defined by an amount or concentration of one or more of a tissue growth inhibitor or anti-tissue agent, an anti-tissue agent or factor, an anti-angiogenic factor, a monoclonal or polyclonal antibody, an antibody fragment, a substance for cellular control, a chemotactic substance for influencing cell-migration, an inhibitory substance for influencing cell-migration, a mitogenic growth factor for influencing cell proliferation, a tissue-inductive factor, a growth factor for influencing cell differentiation, and a factor which promotes angiogenesis, and which is different from a pre-implantation compositional characteristic of the tissue growing side, wherein the substantially planar barrier membrane or resorbable polymer base material is impregnated with at least one of an anti-tissue agent, a chemotactic substance for influencing cell-migration, an inhibitory substance for influencing cell-migration, a mitogenic growth factor for influencing cell proliferation, a growth factor for influencing cell differentiation, and factors which promote angiogenesis.
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8. A method for governing tissue growth in a tissue cavity, comprising:
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providing a smooth-surfaced resorbable polymer barrier membrane—
which is about 10 to 300 microns thick and adapted to be resorbed in about 18 to 24 months and which has a tissue-growing side with a tissue inductive factor and a non-tissue-growing side substantially free of the tissue inductive factor; andinserting the resorbable barrier membrane into a tissue cavity of a patient so that the resorbable barrier membrane defines a tissue-growth area and a non-tissue-growth area, each of the tissue-growth area and the non-tissue-growth area being disposed on opposite sides of the resorbable barrier membrane before the resorbable barrier membrane is resorbed, wherein the resorbable barrier membrane comprises an agent that governs tissue growth by limiting tissue-growth in the non-tissue-growth area relative to a growth of tissue in the tissue-growth area. - View Dependent Claims (9, 10)
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Specification