Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents

  • US 20110144054A1
  • Filed: 12/08/2010
  • Published: 06/16/2011
  • Est. Priority Date: 04/09/1999
  • Status: Active Grant
First Claim
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1. An improved method for administration of a pharmacological composition of the type employing an iron oxide complex with a polyol, wherein the improvement comprises:

  • administering parenterally an effective dose of a terminally sterilizable reduced derivatized polyol iron oxide complex composition prepared in a total volume of biocompatible liquid from about 1 mL to about 15 mL and for a total single dose from about 50 mg to about 600 mg of iron, so that upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis; and

    effecting such administration at a rate substantially greater than 1 mL/min.

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