OPTIMIZATION OF ALGINATE ENCAPSULATION OF ISLETS FOR TRANSPLANTATION
First Claim
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1. Apparatus, comprising:
- a plurality of islets; and
a hydrogel configured to macroencapsulate the plurality of islets, the hydrogel being implantable in a subcapsular space of a kidney of a subject, and shaped to define a planar configuration.
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Abstract
Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
94 Citations
43 Claims
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1. Apparatus, comprising:
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a plurality of islets; and a hydrogel configured to macroencapsulate the plurality of islets, the hydrogel being implantable in a subcapsular space of a kidney of a subject, and shaped to define a planar configuration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method, comprising:
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providing a plurality of islets macroencapsulated in a hydrogel shaped to define a planar configuration; and implanting the macroencapsulated islets in a subcapsular space of a kidney of a subject. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method, comprising:
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providing a plurality of islets macroencapsulated in a hydrogel shaped to define a planar configuration; and implanting the macroencapsulated islets in at least one area of a body of a subject selected from the group consisting of;
a liver of the subject, an area in a vicinity of a diaphragm of the subject, and an omental pouch of the subject.
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36. Apparatus, comprising:
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a plurality of islets having a density of 2,000-8,000 islets/cm̂
2;an alginate structure having a planar configuration that macroencapsulates the plurality of islets, the structure configured to be implanted in a subcapsular space of a kidney of a subject, and having; a longest dimension between 30 mm and 120 mm, a dry matter content of at least 1.6%, and a concentration of guluronic acid of between 40% and 50%. - View Dependent Claims (37, 38, 39)
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40. A method, comprising:
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providing a plurality of islets having a density of 2,000-8,000 islets/cm̂
2 macroencapsulated in an alginate structure having;a planar configuration, a longest dimension between 30 mm and 120 mm, a dry matter content of at least 1.6%, and a concentration of guluronic acid of between 40% and 50%; and implanting in a subcapsular space of a kidney of a subject the alginate structure that macroencapsulates the plurality of islets. - View Dependent Claims (41, 42, 43)
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Specification