PEST-CONTROL COMPOSITIONS AND METHODS HAVING HIGH TARGET AND LOW NON-TARGET ACTIVITY

• US 20110171135A1
• Filed: 07/22/2009
• Published: 07/14/2011
• Est. Priority Date: 07/22/2008
• Status: Abandoned Application

• Current Assignee: TyraTech, Inc. (American Vanguard Corporation)
• Original Assignee: TyraTech, Inc. (American Vanguard Corporation)
• Inventors: Enan, Essam
• Application Number:
  US13/055,429
• Publication Number:
  US 20110171135A1
• Time in Patent Office: Days
• US Class Current: 424/9.2
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/08 Oxygen or sulfur directly attached to an aromatic ring system
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 65/00 Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof containing compounds of determined constitution A01N27/00 - A01N59/00
• CPC Class Codes: A01N 65/16 Ericaceae [Heath or Blueberry family], e.g. rhododendron, arbutus, pieris, cranberry or bilberry
• CPC Class Codes: A01N 65/22 Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint

Abstract

Embodiments of the invention relate to compositions and methods for selective pest control wherein the compositions include active agents that in combination have a first activity against a selected target pest and a second activity against a selected non-target organism and wherein the first activity is greater than the second. Further embodiments of the invention relate to a method for developing selective pest control compositions and low-resistance pest control compositions.

Claims

1-25. -25. (canceled)

26. A method of designing a selective pest control composition, comprising the steps of:

selecting a target pest with a first molecular target and a non-target organism with a second molecular target;

identifying at least two active agents for the composition, wherein the active agents in combination have a first activity upon the first molecular target in a target pest; and

a second activity upon the second molecular target in the non-target organism, and

confirming that the at least two active agents have a synergistic effect upon the target pest and do not have a synergistic effect upon the non-target organism,

wherein the confirming step indicates that the composition is selective for the target pest over the non-target organism.

27. The method of claim 26, wherein the first molecular target is substantially absent in the non-target organism.

28. The method of claim 26, wherein the first molecular target is also present in the non-target organism.

29. The method of claim 26, wherein the first and second activities of the active agents are provided as LD₅₀.

30. The method of claim 29, wherein the ratio of LD₅₀ for the target pest relative to the LD₅₀ for the non-target organism is 0.5.

31. The method of claim 29, wherein the ratio of LD₅₀ for the target pest relative to the LD₅₀ for the non-target organism is 0.1.

32. The method of claim 29, wherein the ratio of LD₅₀ for the target pest relative to the LD₅₀ for the non-target organism is 0.05.

33. The method of claim 29, wherein the ratio of LD₅₀ for the target pest relative to the LD₅₀ for the non-target organism is 0.02.

34. The method of claim 29, wherein the ratio of LD₅₀ for the target pest relative to the LD₅₀ for the non-target organism is 0.01.

35. The method of claim 26, wherein the confirming step comprises confirming that the agents in combination have an effect in the non-target organism selected from the group consisting of:

an antagonistic effect, a non-additive effect, and an additive effect.

36. The method of claim 26, wherein the first molecular target is a G-protein coupled receptor.

37. The method of claim 36, wherein the G-protein coupled receptor is selected from the group consisting of:

a tyramine receptor, an octopamine receptor, olfactory receptor Or83b and olfactory receptor 43a.

38. A method of developing a selective pest control composition, comprising the steps of:

selecting a target pest for selective control by the composition, and a non-target organism to be substantially unaffected by the composition;

identifying at least two active agents for the composition, wherein the active agents in combination have a synergistic effect within the target pest; and

confirming that the identified active agents do not have a synergistic effect within the non-target organism, to establish that the composition is selective of the target pest over the non-target organism.

39. A method of designing a selective pest control composition, comprising the steps of:

selecting a target pest for selective control by the composition and a non-target organism to be substantially unaffected by the composition;

identifying at least two active agents for the composition, wherein the active agents in combination have a first activity upon the target pest; and

a second activity upon the non-target organism, and

confirming that the at least two active agents have a synergistic effect upon the target pest and do not have a synergistic effect upon the non-target organism,

wherein the confirming step indicates that the composition is selective for the target pest over the non-target organism.

40. A method of developing a low-resistance pest control foiuiulation against a target pest, comprising the steps of

selecting a target pest, the pest having at least a first and a second molecular target, where the molecular targets are under genetic control;

selecting at least two active agents, wherein a first active agent interacts with the first molecular target under genetic control and a second active agent interacts with the second molecular target under genetic control; and

combining the two active agents in a formulation, wherein the agents in the formulation act upon the target pest in a synergistic manner, and wherein resistance to the formulation in an individual target pest requires two separate genetic lesions divergent from a non-resistant population of the pest.