Methods and Devices for Tailoring a Bolus Delivery Pattern

• US 20110224646A1
• Filed: 09/10/2009
• Published: 09/15/2011
• Est. Priority Date: 09/11/2008
• Status: Abandoned Application

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Levy, Aharon, Shapira, Gali, Yodfat, Ofer
• Application Number:
  US13/063,677
• Publication Number:
  US 20110224646A1
• Time in Patent Office: Days
• US Class Current: 604/504
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

Methods and devices for delivering therapeutic fluid to the body are described. The method may include determining a bolus delivery pattern based on a specific dietary intake of a patient and delivering the therapeutic fluid into the patient'"'"'s body based, at least in part, on the determined bolus delivery pattern. The devices used in conjunction with the disclosed methods may include a controller to determine a bolus delivery pattern based on a specific dietary intake of the patient and an infusion pump to deliver the therapeutic fluid into the patient'"'"'s body based, at least in part, on the determined bolus delivery pattern.

Claims

1-55. -55. (canceled)

56. A therapeutic fluid dispensing device to deliver therapeutic fluid into the body of a patient, the device comprising:

a controller having instructions operable thereon configured to determine a bolus delivery pattern based on a specific dietary intake of the patient; and

an infusion pump to deliver the therapeutic fluid into the body of the patient based, at least in part, on the determined bolus delivery pattern,

wherein the instructions are further configured to select the bolus delivery pattern from a plurality of bolus delivery patterns,

at least one of the bolus delivery patterns being determined based on at least one of a dietary intake similar to the specific dietary intake of the patient,

and other delivery patterns corresponding to blood glucose responses of one or more non-diabetic individuals that have consumed dietary intakes similar to the specific dietary intake of the patient.

57. The device of claim 56, wherein the controller is configured to determine the bolus delivery patterns based additionally on blood glucose responses of the patient after the patient has consumed dietary intakes similar to the specific dietary intakes.

58. The device of claim 57, wherein for each of the bolus delivery patterns, the controller is configured to compute a difference between an area under the curve of a graphical representation of the response of the patient to a respective type of dietary intake and an area under the curve of a graphical representation of the response of the one or more non-diabetic individuals to the respective type of dietary intake.

59. The device of claim 56, wherein the specific dietary intake comprises a glycemic index representative of the effect of the carbohydrate content of food corresponding to the type of dietary intake on blood glucose levels in individuals consuming the food.

60. The device of claim 56, further comprising a blood glucose sensor to measure the blood glucose level of the patient.

61. The device of claim 60, wherein the blood glucose sensor includes a glucometer.

62. The device of claim 61, wherein the glucometer is disposed in a remote control that further includes the controller.

63. The device of claim 60, wherein the blood glucose sensor includes a continuous glucose monitor.

64. The device of claim 63, wherein the continuous glucose monitor is disposed in a dispensing patch unit that includes the infusion pump.

65. A method for delivering therapeutic fluid, the method comprising:

determining a bolus delivery pattern based on a specific dietary intake of a patient; and

delivering a therapeutic fluid into the body of the patient based, at least in part, on the determined bolus delivery pattern,

wherein determining the bolus delivery pattern includes selecting a bolus delivery pattern from a plurality of bolus delivery patterns,

wherein at least one of the bolus delivery patterns being determined based on at least one of dietary intakes similar to the specific dietary intake of the patient, and other delivery patterns corresponding to blood glucose responses of one or more non-diabetic individuals that have consumed dietary intakes similar to the specific dietary intake of the patient.

66. The method of claim 65, wherein the at least one bolus delivery pattern is additionally based on one or more blood glucose responses from the patient after the patient has consumed dietary intakes similar to the specific dietary intake.

67. The method of claim 66, wherein determining the at least one bolus delivery pattern comprises computing a difference between an area under the curve of a graphical representation of the response of the patient to a respective type of dietary intake and an area under the curve of a graphical representation of the response of the one or more non-diabetic individuals to the respective type of dietary intake.

68. The method of claim 65, further comprising adjusting the determined bolus delivery pattern based on pharmacodynamics characteristics of the therapeutic fluid.

69. The method of claim 68, wherein adjusting the determined bolus delivery pattern based on the pharmacodynamics characteristics of the therapeutic fluid includes time-shifting the determined bolus delivery pattern.

70. The method of claim 65, wherein delivering the therapeutic fluid into the body of the patient comprises pumping insulin stored in a reservoir in a fluid infusion device into the body of the patient.

71. The method of claim 65, further comprising graphically representing the bolus delivery pattern.

72. A method for tailoring a bolus pattern to a patient, the method comprising:

retrieving data related to a healthy response, the data comprising one or more records, each record including a meal type and a corresponding first set of analyte concentration levels for a first period of time occurring after a meal has been consumed by a healthy individual;

initiating a bolus dose administration to the body of the patient;

receiving a second set of analyte concentration levels corresponding to a second period of time, the second period of time occurring after the meal has been consumed by the patient;

correlating the first set of analyte concentration levels and second set of analyte concentration levels; and

determining a bolus delivery pattern associated with the meal consumed by the patient, based on the correlation between the first set of analyte concentration levels and the second set of analyte concentration levels.

73. The method of claim 72, further comprising visually displaying at least one of the first set of analyte concentration levels and the second set of analyte concentration levels.

74. The method of claim 73, wherein visually displaying the at least one of the first set of analyte concentration levels and the second set of analyte concentration levels comprises:

displaying a background image corresponding to the first set of analyte concentration levels, and

displaying a primary image corresponding to the second set of analyte concentration levels,

wherein the primary image is superimposed on the background image.

75. The method of claim 72, further comprising visually displaying the determined bolus delivery pattern.

76. The method of claim 72, comprising providing a therapeutic fluid delivery device including:

a reservoir retaining the therapeutic fluid;

a driving mechanism dispensing the therapeutic fluid from the reservoir to the body of the patient;

a controller controlling the dispensing of the therapeutic fluid, the controller is further capable of correlating the first set of analyte concentration levels and the second set of analyte concentration levels;

a memory storing at least one of the data related to a healthy response, the first set of analyte concentration levels, the second set of analyte concentration levels and the determined bolus delivery pattern; and

a screen displaying at least one of the first set of analyte concentration levels, the second set of analyte concentration levels and the determined bolus delivery pattern.