DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR
First Claim
1. An analyte detection system, comprising:
- an optical fiber sensor comprising a proximal end portion and a distal end portion, wherein a chemical indicator system is disposed along the distal end portion, the chemical indicator system comprising a fluorophore and an analyte binding moiety, which interact to generate a fluorescent signal related to an amount of analyte bound to the analyte binding moiety; and
a deployment device comprisingtelescoping tubes configured to extend and retract at least the distal end portion of the optical fiber sensor, such that sensor integrity, hydration and sterility is maintained during sensor calibration and deployment;
a latch disposed on the telescoping tubes and configured to engage with a base disposed on the telescoping tubes, such that when the latch is engaged with the base the distal end portion of the optical fiber sensor extends by a predetermined length; and
an electrical/optical connector disposed at a proximal end of the deployment device and configured to electrically and optically connect with a cable configured to transmit electrical signals and optical signals to and from a monitor apparatus;
wherein the optical fiber sensor is housed concentrically in the telescoping tubes.
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0 Petitions
Accused Products
Abstract
Embodiments of the invention are directed to a delivery device and method for deploying an optical analyte sensor. The delivery device comprises hollow tubes configured to operate telescopically. The optical sensor is configured to retract and extend from a distal end of the delivery device, by sliding the telescoping tubes with respect to one another. The delivery device may also have a locking mechanism such that the distal end portion of the sensor will extend to a preset locked position beyond the delivery device, e.g., during calibration and deployment. The device is capable of being used to ship, calibrate, and deploy the sensor while maintaining sterility and avoiding exposure to the external environment.
16 Citations
25 Claims
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1. An analyte detection system, comprising:
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an optical fiber sensor comprising a proximal end portion and a distal end portion, wherein a chemical indicator system is disposed along the distal end portion, the chemical indicator system comprising a fluorophore and an analyte binding moiety, which interact to generate a fluorescent signal related to an amount of analyte bound to the analyte binding moiety; and a deployment device comprising telescoping tubes configured to extend and retract at least the distal end portion of the optical fiber sensor, such that sensor integrity, hydration and sterility is maintained during sensor calibration and deployment; a latch disposed on the telescoping tubes and configured to engage with a base disposed on the telescoping tubes, such that when the latch is engaged with the base the distal end portion of the optical fiber sensor extends by a predetermined length; and an electrical/optical connector disposed at a proximal end of the deployment device and configured to electrically and optically connect with a cable configured to transmit electrical signals and optical signals to and from a monitor apparatus; wherein the optical fiber sensor is housed concentrically in the telescoping tubes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of detecting an analyte concentration in a blood vessel, comprising:
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introducing a cannula into the blood vessel;
connecting a distal end of a deployment device to the cannula, wherein the deployment device comprises telescoping tubes configured to extend and retract at least a distal end portion of an analyte sensor;deploying the analyte sensor through the cannula and into the blood vessel by sliding the telescoping tubes with respect to one another; and measuring the analyte concentration by detecting a signal related to the analyte concentration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. An analyte sensor deployment kit, comprising:
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an analyte sensor with proximal and distal end regions, comprising; an optical fiber with proximal and distal ends; a chemical indicator system, optically coupled to the optical fiber and disposed along the distal end region of the analyte sensor, the chemical indicator system being capable of generating an emission light signal related to the analyte concentration upon interrogation with an excitation light signal; a thermocouple disposed along the distal end region of the analyte sensor and comprising a wire that extends proximally along the optical fiber; and a sensor connector located at the proximal end region of the analyte sensor and coupled to the proximal end of the optical fiber and the thermocouple wire; and a deployment system, comprising; a first hollow tube comprising a distal end and a proximal end; a second hollow tube, slidably and coaxially engaged with the first hollow tube, the second hollow tube comprising a distal end and a proximal end; a third hollow tube, slidably and coaxially engaged with the second hollow tube, the third hollow tube comprising a distal end and a proximal end; a connector located at the distal end of the third hollow tube and configured to connect to a first external device; and a multi-connector junction located at the proximal end of the third hollow tube, configured connect to a second external device; wherein the analyte sensor is slidably and coaxially engaged within the first, second and third hollow tubes of the deployment system. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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Specification