DIAGNOSTIC METHODS
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Abstract
This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy.
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36 Claims
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1-16. -16. (canceled)
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17. A method for determining susceptibility to statin-induced myopathy, comprising
(a) determining the presence or absence of a polymorphism in the SLCO1B1 gene in a biological sample obtained from a patient; - and
(b) correlating the presence of said polymorphism with susceptibility to statin-induced myopathy, wherein said polymorphism is SNP rs4149056, rs4363657, rs1871395, rs12317268, rs2900478, rs4149100, rs4149081, rs11045879, rs7969341, rs11045885, rs12369881, rs12366582, or a polymorphism having a linkage disequilibrium with rs4149056 having a squared correlation coefficient of r2 >
0.8. - View Dependent Claims (18, 19, 20)
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21. A method for optimizing statin administration, comprising:
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(a) determining the presence or absence of a polymorphism in the SLCO1B1 gene in a biological sample obtained from a patient in need of statin, wherein said polymorphism is SNP rs4149056, rs4363657, rs1871395, rs12317268, rs2900478, rs4149100, rs4149081, rs11045879, rs7969341, rs11045885, rs12369881, rs12366582, or a polymorphism having a linkage disequilibrium with rs4149056 having a squared correlation coefficient of r2 >
0.8;(b) correlating the presence of said polymorphism with statin-induced myopathy susceptibility; and (c) establishing a suitable statin dosage based on said patient'"'"'s statin-induced myopathy susceptibility. - View Dependent Claims (22, 23, 24)
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25. A method for determining susceptibility to statin-induced myopathy in a patient, comprising:
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(a) obtaining a biological sample from said patient; (b) detecting the presence or absence of a polymorphism in the SLCO1B1 gene in said sample; and (c) recording the presence or absence of said polymorphism, wherein said polymorphism is SNP rs4149056, rs4363657, rs1871395, rs12317268, rs2900478, rs4149100, rs4149081, rs11045879, rs7969341, rs11045885, rs12369881, rs12366582, or a polymorphism having a linkage disequilibrium with rs4149056 having a squared correlation coefficient of r2 >
0.8.- View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
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- 33. A kit for detecting one or more polymorphisms in the SLCO1B1 gene in a biological sample from a patient, wherein said polymorphism is SNP rs4149056, rs4363657, rs1871395, rs12317268, rs2900478, rs4149100, rs4149081, rs11045879, rs7969341, rs11045885, rs12369881, rs12366582, or a polymorphism having a linkage disequilibrium with rs4149056 having a squared correlation coefficient of r2 >
Specification