METHOD FOR DELIVERING GENE AND CELL THERAPY TO A TUMOR OR TARGETED SITE USING AN IMPLANTED METRONOMIC BIOFEEDBACK PUMP
First Claim
1. A method for delivering a viral or non-viral gene vector for gene therapy or a therapeutic agent for cell therapy of a tumor in a patient comprising:
- surgically implanting a fluid-exchange catheter into a treatment site;
coupling the fluid-exchange catheter to an analyzer-pump unit;
operating the analyzer-pump unit to infuse the viral or nonviral vector or the therapeutic agent stored in a reservoir into the treatment site;
suctioning a sample of fluid from the treatment site;
transferring the sample to the analyzer-pump unit;
monitoring progress of treatment by means of the analyzer-pump unit;
changing the treatment by controlling the analyzer-pump unit; and
refilling or replacing a reservoir containing the viral or nonviral vector or therapeutic agent.
1 Assignment
0 Petitions
Accused Products
Abstract
A method for utilizing a controlled pump implanted into a patient connected to a multilumen catheter allowing delivery to and sampling from the brain or other organ for treatment of a cancer. The pump delivers a plurality of medicating agents, including viral and non-viral vectors for gene therapy and cell therapy at a controlled rate, corresponding to the specific needs of the patient. A catheter is implanted in or adjacent to the tumoral region. Fluid drawn from the tumor region to the pump via the multilumen catheter is analyzed within the pump by various biofeedback sensors. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. The method allows localized delivery of gene and cell therapy to a solid tumor or tumoral region, or to any other treatment area of interest within the patient.
14 Citations
20 Claims
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1. A method for delivering a viral or non-viral gene vector for gene therapy or a therapeutic agent for cell therapy of a tumor in a patient comprising:
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surgically implanting a fluid-exchange catheter into a treatment site; coupling the fluid-exchange catheter to an analyzer-pump unit; operating the analyzer-pump unit to infuse the viral or nonviral vector or the therapeutic agent stored in a reservoir into the treatment site; suctioning a sample of fluid from the treatment site; transferring the sample to the analyzer-pump unit; monitoring progress of treatment by means of the analyzer-pump unit; changing the treatment by controlling the analyzer-pump unit; and refilling or replacing a reservoir containing the viral or nonviral vector or therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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6. The method of claim where changing the treatment by controlling the analyzer-pump unit further comprises entering a command or data into the analyzer-pump unit from a remote keypad and displaying the commands on a display.
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19. An apparatus for delivering a viral or non-viral gene vector for gene therapy or a therapeutic agent for cell therapy of a tumor in a patient comprising:
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a fluid-exchange catheter adapted for surgical implantation into a treatment site; an analyzer-pump unit fluidicly communicated with the fluid-exchange catheter; a refillable or replaceable reservoir fluidicly communicated with the analyzer-pump unit to infuse the viral or nonviral vector or the therapeutic agent stored in a reservoir into the treatment site; where the analyzer-pump unit suctions a sample of fluid from the treatment site, analyzes the sample to monitor the treatment, where the analyzer-pump unit is controllable to change the treatment in response to monitoring. - View Dependent Claims (20)
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Specification