SYSTEMS AND METHODS FOR LIMB TREATMENT

• US 20130079697A1
• Filed: 08/10/2012
• Published: 03/28/2013
• Est. Priority Date: 08/11/2011
• Status: Active Grant

• Current Assignee: David Martin Kaye
• Original Assignee: David Martin Kaye
• Inventors: Kaye, David Martin
• Granted Patent: US 9,211,372 B2
• Time in Patent Office: Days
• US Class Current: 604/6.16
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 2202/0021 removed from and reintroduced into the body, e.g. after treatment
• CPC Class Codes: A61M 2210/086 Legs
• CPC Class Codes: A61M 2210/12 Blood circulatory system
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps

Abstract

A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.

Claims

1. A method of delivering a medicament to a limb of a patient body, the method comprising:

isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system comprises substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb;

inserting a perfusion catheter into a limb artery of the limb circulatory system in an antegrade position;

inserting a collection catheter into a limb vein of the limb circulatory system in a retrograde position;

circulating substantially all of a blood flow of the limb circulatory system by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter; and

perfusing a medicament to the limb circulatory system with the perfusion catheter.

2. The method of claim 1, wherein the isolating operation comprises applying a tourniquet to the limb.

3. The method of claim 1, wherein the isolating operation comprises expanding an occlusion device surrounding the perfusion catheter and expanding an occlusion device surrounding the collection catheter.

4. The method of claim 1, further comprising expanding a support structure within the limb artery, prior to the circulating operation.

5. The method of claim 4, wherein the support structure comprises a plurality of expandable members, wherein the expandable members are located at least partially within the collection catheter during the inserting step.

6. The method of claim 4, wherein the support structure comprises a plurality of expandable members, wherein the expandable members are located both internal and external to the collection catheter during the inserting step, and wherein at least one expandable member is secured to a distal end of the collection catheter.

7. The method of claim 1, wherein the circulating step is performed with a pump located external to the patient body.

8. The method of claim 1, further comprising at least one of oxygenating the blood flow and heating the blood flow.

9. The method of claim 1, wherein the medicament comprises at least one of antibiotics, anti-thrombin agents, anti-platelet agents, anti-spasm agents, and thrombolytic agents.

10. The method of claim 1, wherein the medicament comprises Timentin.

11. The method of claim 7, wherein the pump circulates the blood flow at a rate of about 200 ml per minute to about 300 ml per minute.

12. A method of delivering a medicament to a limb of a patient body in a retrograde orientation, the method comprising:

inserting a perfusion catheter into a limb vein of the limb circulatory system in a retrograde position;

inserting a collection catheter into a limb artery of the limb circulatory system in a antegrade position;

isolating a flow of blood within the limb from a flow of a systemic flow of blood;

circulating substantially all of a blood flow of the limb circulatory system by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter; and

perfusing a medicament to the limb circulatory system with the perfusion catheter.

13. The method of claim 12, wherein the perfusion catheter comprises a selectively expandable occlusion member substantially surrounding the catheter, and a delivery end located distal from the occlusion member.

14. The method of claim 13, wherein the delivery end defines a plurality of openings.

15. The method of claim 13, wherein the step of inserting the perfusion catheter comprises spanning a plurality of venous valves with the delivery end of the perfusion catheter.

16. The method of claim 15, wherein the delivery end comprises a spring.

17. The method of claim 13, wherein the selectively expandable occlusion member is movably displaceable along the delivery end of the perfusion catheter.

18. The method of claim of 17, wherein the selectively expandable occlusion member is located on the delivery end of the perfusion catheter so as to at least partially occlude at least one of the plurality of openings of the delivery end of the perfusion catheter.