Systems and methods for limb treatment

• US 9,211,372 B2
• Filed: 08/10/2012
• Issued: 12/15/2015
• Est. Priority Date: 08/11/2011
• Status: Active Grant

• Current Assignee: Osprey Medical, Inc.
• Original Assignee: Osprey Medical, Inc.
• Inventors: Kaye, David Martin
• Primary Examiner(s): DEAK, LESLIE R
• Application Number:
  US13/571,823
• Publication Number:
  US 20130079697A1
• Time in Patent Office: 1,222 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 2202/0021 removed from and reintroduced into the body, e.g. after treatment
• CPC Class Codes: A61M 2210/086 Legs
• CPC Class Codes: A61M 2210/12 Blood circulatory system
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps

Abstract

A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.

Claims

1. A method of delivering a medicament to a limb of a patient body, the method comprising:

isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system comprises substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb;

inserting a perfusion catheter into a limb artery of the limb circulatory system in an antegrade position;

inserting a collection catheter into a limb vein of the limb circulatory system in a retrograde position, wherein an expandable non-occlusive support structure is at least partially disposed in the collection catheter during insertion, and wherein the perfusion catheter and the collection catheter each comprise an occlusion member constructed so as to move along a respective catheter;

extending the expandable non-occlusive support structure from the collection catheter so as to expand the expandable non-occlusive support structure within the limb vein;

circulating substantially all of a blood flow of the limb circulatory system by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter; and

perfusing a medicament to the limb circulatory system with the perfusion catheter.

2. The method of claim 1, wherein the isolating operation comprises applying a tourniquet to the limb.

3. The method of claim 1, wherein the isolating operation comprises expanding an occlusion device surrounding the perfusion catheter and expanding an occlusion device surrounding the collection catheter.

4. The method of claim 1, wherein the expandable non-occlusive support structure comprises a plurality of expandable members.

5. The method of claim 1, wherein the expandable non-occlusive support structure comprises a plurality of expandable members, and wherein at least one expandable member is secured to a distal end of the collection catheter.

6. The method of claim 1, wherein the circulating step is performed with a pump located external to the patient body.

7. The method of claim 6, wherein the pump circulates the blood flow at a rate of about 200 ml per minute to about 300 ml per minute.

8. The method of claim 1, further comprising at least one of oxygenating the blood flow and heating the blood flow.

9. The method of claim 1, wherein the medicament comprises at least one of antibiotics, anti-thrombin agents, anti-platelet agents, anti-spasm agents, and thrombolytic agents.

10. The method of claim 1, wherein the medicament comprises Timentin.