COMPOSITIONS AND APPLICATIONS OF CAROTENOIDS OF IMPROVED ABSORPTION AND BIOAVAILABILITY

• US 20140099386A1
• Filed: 12/09/2013
• Published: 04/10/2014
• Est. Priority Date: 12/21/2010
• Status: Abandoned Application

• Current Assignee: Industrial Orgnica SA de CV
• Original Assignee: Industrial Organica, S.A. De C.V.
• Inventors: Montoya-Olvera, Ricardo, Torres-Quiroga, Jose-Odon
• Application Number:
  US14/100,401
• Publication Number:
  US 20140099386A1
• Time in Patent Office: Days
• US Class Current: 424/638
• CPC Class Codes: A23K 20/158 Fatty acids; Fats; Products containing oils or fats
• CPC Class Codes: A23K 20/174 Vitamins
• CPC Class Codes: A23K 20/179 Colouring agents, e.g. pigmenting or dyeing agents
• CPC Class Codes: A23K 20/30 Oligoelements
• CPC Class Codes: A23K 50/75 for poultry
• CPC Class Codes: A23K 50/80 for aquatic animals, e.g. fish, crustaceans or molluscs
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 5/44 using carotenoids or xanthophylls
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/121 acyclic
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 33/04 : Sulfur, selenium or tellurium; Compounds thereof
• CPC Class Codes: A61K 33/30 : Zinc; Compounds thereof
• CPC Class Codes: A61K 33/32 : Manganese; Compounds thereof
• CPC Class Codes: A61K 33/34 : Copper; Compounds thereof
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/44 : Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 9/1075 : Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61K 9/4858 : Organic compounds
• CPC Class Codes: Y02A 40/818 : Alternative feeds for fish, e.g. in aquacultures

Abstract

Micro-micelle forms of carotenoids and/or xanthophylls, which show improved absorption and biovailability by living organisms, provide higher levels of carotenoids in the blood stream, and consequently are deposited at the target tissues at a faster rate and more efficiently than crystalline carotenoids are provided. The micro-micelle forms do not contain any crystal forms of carotenoids, and are obtained as micro-micelles after melting Lutein diacetate or Lutein dipropionate in their natural original lipid vegetable matrix, in the presence of lipids, phospholipids, fatty acids, emulsifiers and moisture. The micro-micelle forms can be ingested at a dosage between 2 mg to 50 mg to provide an absorption of the carotenoid solubilizate that is at least 20% above that of crystalline carotenoids, and provides a macular pigment deposit that exceeds at least 10% of Macular Pigment Optical Density, than the deposition obtained by ingesting crystalline Lutein.

Claims

1. A composition, comprising:

a solubilizate form of a xanthophyll which does not contain any crystal forms of carotenoids, the xanthophyll solubilizate being in the form of micro-micelles obtained by melting a xanthophyll diacetate or a xanthophyll dipropionate in their natural original lipid vegetable matrix in the presence of lipids, phospholipids, fatty acids, emulsifiers and moisture, in a dosage between 2 to 50 mg, wherein the xanthophyll solubilizate

provides an absorption that is at least 20% greater than that of crystalline carotenoids, and

provides an improved bioavailability in the macular pigment deposit that exceeds by at least 10% of the Macular Pigment Optical Density the bioavailability obtained by ingesting crystalline xanthophylls; and

at least one of zinc, copper, selenium, manganese, vitamin A, vitamin C, and vitamin E.

2. The composition according to claim 1, wherein said dosage is between 8 mg to 10 mg.

3. The composition according to claim 1, wherein said dosage is 20 mg.

4. The composition according to claim 1, wherein the solubilizate form of a xanthophyll is dispersed in an oil rich in Omega-3 and Omega-6 fatty acids.

5. The composition according to claim 1, wherein the solubilizate comprises lutein in the form of micro-micelles that is better absorbed and is more bioavailable than the crystalline form.

6. The composition according to claim 1, wherein the solubilizate comprises 3′

epilutein in the form of micro-micelles that is better absorbed and more bioavailable than the crystalline form.

7. The composition according to claim 1, wherein the solubilizate comprises 3R,3′

R zeaxanthin in the form of micro-micelles.

8. The composition according to claim 1, wherein the solubilizate comprises 3R,3′

R zeaxanthin short chain diesters, dispersed in an oil rich in Omega-3 and Omega-6 fatty acids.

9. The composition according to claim 1, wherein the solubilizate comprises 3R,3′

R meso-zeaxanthin in the form of micro-micelles.

10. The composition according to claim 1, wherein the solubilizate comprises 3R,3′

R meso-zeaxanthin short chain diesters, dispersed in an oil rich in Omega-3 and Omega-6 fatty acids.

11. The composition according to claim 1, wherein the solubilizate comprises capsanthin in the form of micro-micelles.

12. The composition according to claim 1, wherein the solubilizate comprises capsorubin in the form of micro-micelles.

13. The composition according to claim 1, wherein the solubilizate comprises astaxanthin in the form of micro-micelles.

14. The composition according to claim 1, wherein the solubilizate comprises astaxanthin short chain diesters, dispersed in an oil rich in Omega-3 and Omega-6 fatty acids.

15. The composition according to claim 1, wherein the solubilizate comprises cryptoxanthin short chain monoesters in the form of micro-micelles.

16. The composition according to claim 1, wherein the solubilizate comprises lutein, 3′

epilutein, 3R,3′

R zeaxanthin, 3R,3′

R meso-zeaxanthin, capsanthin, capsorubin, astaxanthin and cryptoxanthin, in the form of micro-micelles,

formulated in a liquid preparation, water or other edible liquid, as an edible oil dispersion, as microcapsules, or dispersed in inert carriers.

17. The composition according to claim 1, wherein the xanthophyll of said the solubilizate is a form of lutein, 3′

epilutein, 3R,3′

R zeaxanthin, 3R,3′

R meso-zeaxanthin, or astaxanthin in a micro-micelle preparation, alone or in combination in an amount between about 2 mg to 50 mg, to prevent or treat one or more of maculopathy disorders, AMD, cataracts, tissue degeneration and UV light damage to skin or to the retina, wherein said solubilizate acts as a more effective and efficient antioxidant than when administered in crystalline form.

18. The composition according to claim 1, wherein the xanthophyll of said solubilizate is a form of 3R,3′

R zeaxanthin, 3R,3′

R meso-zeaxanthin, capsanthin, or astaxanthin in a micro-micelle preparation, alone or in combination, in an amount between about 2 mg to 50 mg, for egg color and skin pigmentation in poultry, and as an antioxidant and for UV protection in marine species and crustaceans.