NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES
9 Assignments
0 Petitions
Accused Products
Abstract
Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
41 Citations
19 Claims
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1. (canceled)
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2. A pharmaceutical composition comprising:
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solubilized estradiol; suspended progesterone; and a solubilizing agent; wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed; wherein at least about 90% of the estradiol is solubilized in the solubilizing agent; and wherein the solubilizing agent comprises an effective amount of a monoglyceride, a diglycerides or a combination thereof containing an ester of a C6-C12 fatty acid. - View Dependent Claims (3, 4, 5, 6, 7)
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8. A pharmaceutical composition comprising:
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solubilized estradiol; suspended progesterone; and a solubilizing agent; wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed; wherein at least about 90% of the estradiol is solubilized in the solubilizing agent; and wherein the solubilizing agent comprises an effective amount of a monoglyceride, a diglycerides or a combination thereof containing an ester of a C6-C12 fatty acid. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A pharmaceutical composition comprising:
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solubilized estradiol; suspended progesterone; and a solubilizing agent; wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed; wherein at least about 90% of the estradiol is solubilized in the solubilizing agent; and wherein the solubilizing agent comprising an effective amount of a diglyceride containing an ester of a C6-C12 fatty acid. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification