HEART FAILURE EVENT PREDICTION USING CLASSIFIER FUSION
First Claim
1. A system, comprising:
- a physiologic signal receiver circuit configured to receive at least one physiologic signal obtained from a patient;
two or more partial predictor circuits, each including;
a feature generator circuit configured to generate one or more candidate signal features from the at least one physiologic signal;
a dynamic computational model circuit configured to adaptively generate a dynamic computational model; and
a partial risk calculator circuit configured to calculate a partial risk index using the one or more candidate signal features and the dynamic computational model, the partial risk index indicating a likelihood of the patient developing a precursor physiologic event indicative or correlative of a future target physiologic event; and
a prediction fusion circuit coupled to the two or more partial predictor circuits, the prediction fusion circuit configured to generate a composite risk indicator using the partial risk indices produced by the two or more partial predictor circuits, the composite risk indicator indicative of a likelihood of the patient developing the future target physiologic event.
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Accused Products
Abstract
Systems and methods for detecting a heart failure (HF) event indicative of worsening of HF, or for identifying patient at elevated risk of developing future HF event, are described. The system and methods can detect an HF event or predict HF risk using a multitude of fusion algorithms or classifiers, each employing one or more physiologic sensor signals. A system can comprise two or more partial predictor circuits each can adaptively generate a dynamic computational model (DCM). Each partial predictor circuit can determine a partial risk index indicating a likelihood of the patient developing a precursor physiologic event indicative or correlative of a future HF event. The system can include a prediction fusion circuit that can combine the partial risk indices and generate a composite risk indicator for detecting or predicting a likelihood of the patient developing a future HF event.
39 Citations
20 Claims
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1. A system, comprising:
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a physiologic signal receiver circuit configured to receive at least one physiologic signal obtained from a patient; two or more partial predictor circuits, each including; a feature generator circuit configured to generate one or more candidate signal features from the at least one physiologic signal; a dynamic computational model circuit configured to adaptively generate a dynamic computational model; and a partial risk calculator circuit configured to calculate a partial risk index using the one or more candidate signal features and the dynamic computational model, the partial risk index indicating a likelihood of the patient developing a precursor physiologic event indicative or correlative of a future target physiologic event; and a prediction fusion circuit coupled to the two or more partial predictor circuits, the prediction fusion circuit configured to generate a composite risk indicator using the partial risk indices produced by the two or more partial predictor circuits, the composite risk indicator indicative of a likelihood of the patient developing the future target physiologic event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system, comprising:
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a dynamic computational model unit, including; a memory circuit configured to receive and store physiologic data; and a model update circuit adaptively generate two or more dynamic computational models using the stored physiologic data; and an ambulatory medical device communicatively coupled to the dynamic computational model unit, the ambulatory medical device including; a receiver circuit configured to receive from the dynamic computational model unit the two or more dynamic computational models; a physiologic signal receiver circuit configured to receive at least one physiologic signal obtained from a patient; two or more partial predictor circuits configured to generate one or more candidate signal features from the at least one physiologic signal, and to calculate a partial risk index using the one or more candidate signal features and the two or more dynamic computational models, the partial risk index indicating a likelihood of the patient developing a precursor physiologic event indicative or correlative of a future target physiologic event; and a prediction fusion circuit coupled to the two or more partial predictor circuits, the prediction fusion circuit configured to generate a composite risk indicator using the partial risk indices produced by two or more partial predictor circuits, the composite risk indicator indicative of a likelihood of the patient developing the future target physiologic event. - View Dependent Claims (15, 16)
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17. A method, comprising:
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adaptively generating at least first and second dynamic computational models; receiving at least one physiologic signal obtained from a patient; generating one or more candidate signal features using the at least one physiologic signal; calculating a first partial risk index using first signal features and the first dynamic computational model and calculating a second partial risk index using second signal features and the second dynamic computational model, the first and second signal features respectively selected from the one or more candidate signal features, the first partial risk index indicating a likelihood of the patient developing a first precursor physiologic event, the second partial risk index indicating a likelihood of the patient developing a second precursor physiologic event, the first and second precursor physiologic events indicative or correlative of a future target physiologic event; generating a composite risk indicator using one or both of the first and second partial risk indices, the composite risk indicator indicative of a likelihood of the patient developing the future target physiologic event. - View Dependent Claims (18, 19, 20)
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Specification