EX VIVO ORGAN CARE SYSTEM
First Claim
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1. A perfusion circuit for perfusing a liver ex-vivo comprising:
- a pump for providing pulsatile fluid flow of a perfusion fluid through the circuit;
a gas exchanger;
a divider in fluid communication with the pump configured to divide the perfusion fluid flow into a first branch and a second branch;
wherein the first branch comprises a hepatic artery interface;
wherein the first branch is configured to provide a first portion of the perfusion fluid to a hepatic artery of the liver at a high pressure and low flow rate via the hepatic artery interface;
wherein the first branch is in fluid pressure communication with the pump;
wherein the second branch comprises a portal vein interface;
wherein the second branch is configured to provide a second portion of the perfusion fluid to a portal vein of the liver at a low pressure and high flow rate via the portal vein interface;
the second branch further comprising a clamp located between the divider and the portal vein interface for selectively controlling the flow rate of perfusion fluid to the portal vein;
the second branch further comprising a compliance chamber configured to reduce the pulsatile flow characteristics of the perfusion fluid from the pump to the portal vein;
wherein the pump is configured to communicate fluid pressure through the first and second branches to the liver;
a drain configured to receive perfusion fluid from an inferior vena cava of the liver; and
a reservoir positioned below the liver and located between drain and the pump, configured to receive the perfusion fluid from the drain and store a volume of fluid.
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Abstract
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
59 Citations
20 Claims
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1. A perfusion circuit for perfusing a liver ex-vivo comprising:
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a pump for providing pulsatile fluid flow of a perfusion fluid through the circuit; a gas exchanger; a divider in fluid communication with the pump configured to divide the perfusion fluid flow into a first branch and a second branch; wherein the first branch comprises a hepatic artery interface; wherein the first branch is configured to provide a first portion of the perfusion fluid to a hepatic artery of the liver at a high pressure and low flow rate via the hepatic artery interface; wherein the first branch is in fluid pressure communication with the pump; wherein the second branch comprises a portal vein interface; wherein the second branch is configured to provide a second portion of the perfusion fluid to a portal vein of the liver at a low pressure and high flow rate via the portal vein interface; the second branch further comprising a clamp located between the divider and the portal vein interface for selectively controlling the flow rate of perfusion fluid to the portal vein; the second branch further comprising a compliance chamber configured to reduce the pulsatile flow characteristics of the perfusion fluid from the pump to the portal vein; wherein the pump is configured to communicate fluid pressure through the first and second branches to the liver; a drain configured to receive perfusion fluid from an inferior vena cava of the liver; and a reservoir positioned below the liver and located between drain and the pump, configured to receive the perfusion fluid from the drain and store a volume of fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for perfusing an ex vivo liver at near physiologic conditions comprising:
a perfusion circuit comprising; a pump for pumping perfusion fluid through the circuit; the pump in fluid communication with a hepatic artery interface and a portal vein interface; wherein the pump provides perfusion fluid to a hepatic artery of the liver at a high pressure and low flow rate via the hepatic artery interface; and wherein the pump provides perfusion fluid to the a portal vein of the liver at a low pressure and high flow rate via the portal vein interface; a gas exchanger; a heating subsystem for maintaining the temperature of the perfusion fluid at a normothermic temperature; a drain configured to receive the perfusion fluid from an inferior vena cava of the liver; a reservoir configured to receive perfusion fluid from the drain and store a volume of fluid. - View Dependent Claims (9, 10, 11, 12)
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13. A system for preserving a liver ex vivo at physiologic conditions comprising:
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a multiple use module comprising a pulsatile pump; a single use module comprising; a perfusion circuit configured to provide perfusion fluid to the liver; a pump interface assembly for translating pulsatile pumping from the pump to the perfusion fluid; a hepatic artery interface configured to deliver perfusion fluid to a hepatic artery of the liver; a portal vein interface configured to deliver perfusion fluid to a portal vein of the liver; a divider to supply perfusion fluid flow from the pump interface assembly to the hepatic artery interface at a high pressure and low flow rate and to the portal vein interface at a low pressure and high flow rate; an organ chamber assembly configured to hold an ex vivo organ, the organ chamber assembly including a housing; a flexible support surface suspended within the organ chamber assembly; and a bile container configured to collect bile produced by the liver. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification