Natural Polymer-Based Porous Orthopedic Fixation Screw for Bone Repair and Regeneration
First Claim
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1. A bone fixation device comprising:
- a cellulose acetate-hydroxyl apatite composite, wherein the composite comprises 15% hydroxyl apatite and wherein the cellulose acetate has a molecular weight of 30,000 Da or 50,000 Da, wherein the composite is comprised of fused microspheres having a diameter of between 50 um and 400 um.
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Abstract
A bone fixation device made of polysaccharide particles or microspheres fused into a solid structure is provided herein. The bone fixation device may be in the form of an orthopedic screw, orthopedic pin, or orthopedic plate. Methods of making the bone fixation devices described herein are provided as are methods of treating patients in need of bone repair or replacement by implanting a bone fixation device described herein in the patient at a site of bone damage, ligament damage, or bone deformity.
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7 Claims
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1. A bone fixation device comprising:
- a cellulose acetate-hydroxyl apatite composite, wherein the composite comprises 15% hydroxyl apatite and wherein the cellulose acetate has a molecular weight of 30,000 Da or 50,000 Da, wherein the composite is comprised of fused microspheres having a diameter of between 50 um and 400 um.
- View Dependent Claims (2, 3, 4, 5)
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6. A method of making a bone fixation device comprising providing a plurality of polysaccharide microspheres or polysaccharide particles in a mold, wherein the mold is in the form of the bone fixation device;
- providing a solvent system having an organic solvent fraction and an aqueous fraction dropwise in the mold;
removing excess solvent from the mold; and
drying the microspheres or particles in the mold.
- providing a solvent system having an organic solvent fraction and an aqueous fraction dropwise in the mold;
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7. A method of treating a patient in need of bone repair, comprising implanting a bone fixation device in the patient at a site of bone damage, ligament damage, or bone deformity, wherein the device consists of a cellulose acetate-hydroxyl apatite composite, wherein the composite comprises 15% hydroxyl apatite and wherein the cellulose acetate has a molecular weight of at least 30,000 Da.
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