FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND METHOD FOR ITS PRODUCTION
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed are a modified FIX (factor IX) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or tyrosine in position 338; pharmaceutical preparations containing said modified FIX polypeptide; a nucleotide sequence coding for the modified FIX polypeptide; and a method for producing the modified FIX polypeptide.
2 Citations
16 Claims
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1-10. -10. (canceled)
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11. An adeno-associated virus vector comprising:
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a. a nucleic acid encoding a modified FIX polypeptide, the modified FIX polypeptide comprising at least 70% identity to SEQ ID NO;
2 and a leucine in position 338 of SEQ ID NO;
2; andb. promoter sequences, transcription termination, and control elements. - View Dependent Claims (12, 13, 14, 15, 16)
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Specification