SYSTEMS AND METHODS FOR OPTOCHEMICAL IMAGING OF A CHEMICALLY ACTIVE SURFACE

• US 20180292325A1
• Filed: 06/23/2016
• Published: 10/11/2018
• Est. Priority Date: 06/23/2015
• Status: Abandoned Application

• Current Assignee: Case Western Reserve University
• Original Assignee: Case Western Reserve University
• Inventors: Gratzl, Miklos, Ahuja, Punkaj, Hemphill, Brian
• Application Number:
  US15/577,981
• Publication Number:
  US 20180292325A1
• Time in Patent Office: Days
• CPC Class Codes: G01N 2021/775 Indicator and selective membrane
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G01N 21/80 Indicating pH value
• CPC Class Codes: G01N 2201/062 LED's

Abstract

The present disclose generally relates to optochemical imaging of a chemically active surface. A system that can facilitate such optochemical imaging can include an analyte-permeable membrane configured to prevent diffusion of outside contaminates into the system. The analyte permeable membrane comprising: a first surface; and a second surface opposed to the first surface configured to contact a chemically-active surface to permit diffusion of an analyte into the system from the chemically-active surface. The system also includes a measurement component coupled to the analyte-permeable membrane and configured to interact with the analyte. The interaction between the analyte and the measurement component causes a detectable change of a property of the measurement component.

Claims

1. A system comprising:

an analyte-permeable membrane configured to prevent diffusion of outside contaminates into the system, the analyte permeable membrane comprising;

a first surface; and

a second surface opposed to the first surface configured to contact a chemically-active surface to permit diffusion of an analyte into the system from the chemically-active surface; and

a measurement component coupled to the analyte-permeable membrane and configured to interact with the analyte,

wherein the interaction between the analyte and the measurement component causes a detectable change of a property of the measurement component.

2. The system of claim 1 wherein the analyte-permeable membrane comprises a thickness from 10 mm to 500 mm.

3. The system of claim 1, wherein the measurement component comprises an optode membrane.

4. The system of claim 1, wherein the measurement component comprises a plurality of optode beads dispersed within at least a portion of the analyte-permeable membrane.

5. The system of claim 1, wherein at least a portion of the second surface comprises an adhesive surface,

wherein the adhesive surface is configured to secure the system to a location on the chemically-active surface.

6. The system of claim 1, further comprising:

a microfluidic component configured to obtain a sample comprising the analyte; and

a connecting component configured to allow the sample to interact with the analyte-permeable membrane to facilitate the diffusion of the analyte into the system.

7. The system of claim 1, wherein the analyte-permeable membrane comprises a hydrogel membrane.

8. The system of claim 1, further comprising a reference system configured to provide a comparison with regard to the detectable change of the property of the measurement component.

9. The system of claim 1, further comprising an imaging system configured to facilitate detection of the detectable change of the property of the measurement component.

10. The system of claim 9, wherein the imaging system comprises an illumination source, a transducer, a material for transmitting light, and a power source.

11. The system of claim 10, wherein the imaging system comprises a mobile device to display a visualization illustrating the detectable change of the property of the measurement component.

12. The system of claim 10, wherein the material for transmitting light comprises a fiber optic cable, the illumination source comprises a light emitting diode and the transducer comprises at least one photodiode.

13. The system of claim 10, wherein at least one of the illumination source comprises an organic light emitting diode (LED) and the power source comprises an Energy Harvesting Device (EHD).

14. The system of claim 1, wherein the change of the property comprises at least one of an electrochemical change, a fluorescence change, a luminescence change, a change in absorption, a conductometric change, and a coulometric change.

15. The system of claim 1, further comprising a mechanism configured to communicate an indication related to the detectable change of the property of the measurement component to an end user.

16. The system of claim 14 wherein the mechanism comprises at least one of a local active display and a remote monitoring station.

17. A method comprising:

placing a sensing mechanism onto a chemically-active surface, wherein the sensing mechanism comprises an analyte-permeable membrane configured to prevent diffusion of outside contaminates into the system, the analyte permeable membrane while permitting diffusion of an analyte into the sensing mechanism and a measurement component coupled to the analyte-permeable membrane and configured to interact with the analyte; and

changing of a property of the measurement component based on an interaction between the measurement component and the analyte,

wherein the change of the property of the measurement component correlates to a property of the analyte.

18. The method of claim 17, wherein the measurement component comprises a plurality of optode beads dispersed within at least a portion of the analyte-permeable membrane or an optode membrane.

19. The method of claim 17, further comprising displaying, by a system comprising a processor, a visualization illustrating at least one of the detectable change of the property of the measurement component or the correlated property of the analyte.

20. The method of claim 17, further securing the sensing mechanism to a location on the chemically-active surface.