MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
First Claim
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1. A method of administering cromolyn sodium to a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising cromolyn sodium using a device that produces an aerosol of the pharmaceutical composition exhibiting a respirable fraction (≤
- 5 μ
m) of at least about 60%, and wherein administration of the pharmaceutical composition comprising from about 40 mg to about 80 mg of cromolyn sodium to the subject produces in the subject an AUC(0-∞
) of the cromolyn sodium greater than about 120 ng*hr/mL.
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Abstract
Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
2 Citations
20 Claims
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1. A method of administering cromolyn sodium to a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising cromolyn sodium using a device that produces an aerosol of the pharmaceutical composition exhibiting a respirable fraction (≤
- 5 μ
m) of at least about 60%, and wherein administration of the pharmaceutical composition comprising from about 40 mg to about 80 mg of cromolyn sodium to the subject produces in the subject an AUC(0-∞
) of the cromolyn sodium greater than about 120 ng*hr/mL. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 17)
- 5 μ
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13. A method of administering cromolyn sodium to a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising cromolyn sodium using a device that produces an aerosol of the pharmaceutical composition exhibiting a respirable fraction (≤
- 5 μ
m) of at least about 60%, and wherein administration of the pharmaceutical composition comprising from about 40 mg to about 80 mg of cromolyn sodium to the subject produces in the subject a Cmax of the cromolyn sodium greater than about 55 ng/mL. - View Dependent Claims (14, 15, 16, 18, 19, 20)
- 5 μ
Specification