PREPARATION AND APPLICATION OF Syzygium zeylanicum L. EXTRACT

• US 20190321431A1
• Filed: 12/03/2018
• Published: 10/24/2019
• Est. Priority Date: 04/24/2018
• Status: Abandoned Application

• Current Assignee: Tamkang University
• Original Assignee: Tamkang University
• Inventors: WANG, SAN-LANG, NGUYEN, VAN-BON, NGUYEN, ANH-DZUNG, NGUYEN, QUANG-VINH
• Application Number:
  US16/207,713
• Publication Number:
  US 20190321431A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 2236/15 involving mechanical treatment, e.g. chopping up, cutting or grinding
• CPC Class Codes: A61K 2236/331 using water, e.g. cold water, infusion, tea, steam distillation, decoction subcritical water extraction A61K2236/37
• CPC Class Codes: A61K 2236/51 Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

A preparation and application of Syzygium zeylanicum L. extract, which is produced by solvent extraction. The extract can reduce α-glucosidases and α-amylases after administration in vivo and does not cause side effects, further can control the abnormal performance of blood sugar in diabetic patients after meals.

Claims

1. An application of Syzygium zeylanicum L. extract, characterized in that Syzygium zeylanicum L. extract is used to prepare an orally pharmaceutical for inhibiting alpha-glucosidase.

4. The application of the Syzygium zeylanicum L. extract according to claim 1, wherein the oral dosage of the Syzygium zeylanicum L. extract is from 50 mg/kg to 200 mg/kg.

5. The application of the Syzygium zeylanicum L. extract according to claim 1, wherein the Syzygium zeylanicum L. extract is prepared as following steps:

Step 1;

grinding a portion of Syzygium zeylanicum L. at room temperature into a powder;

Step 2;

mixing the powder and a solvent at a ratio of 1;

10 by volume, and shaking at room temperature for 24 hours, and producing a mixture;

Step 3;

filtering the mixture of the step 2, and producing a residue and an extract;

Step 4;

mixing the residue of the step 3 and the solvent of the step 2 by 20 times volume of the powder of the step 1, and then shaking at room temperature for 24 hours;

Step 5;

repeat at least once of the steps 3 and 4, and collecting the extract;

Step 6;

vacuum drying the extract at 60°

C. to obtain Syzygium zeylanicum L. extract and storing at −

30°

C.

6. The application of the Syzygium zeylanicum L. extract according to claim 5, wherein the solvent is selected from the group consisting of ionic water, butanol, ethyl acetate, methanol and ethanol.

7. The application of the Syzygium zeylanicum L. extract according to claim 6, wherein the solvent is ethyl acetate.

8. The application of the Syzygium zeylanicum L. extract according to claim 5, wherein the portion of the Syzygium zeylanicum L. is selected from the group consisting of bark, fruit and leaves.

9. The application of the Syzygium zeylanicum L. extract according to claim 8, wherein the portion of the Syzygium zeylanicum L. is bark.

2. An application of Syzygium zeylanicum L. extract, characterized in that Syzygium zeylanicum L. extract is used to prepare an orally pharmaceutical for inhibiting alpha-amylase.

3. The application of the Syzygium zeylanicum L. extract according to claim 2, wherein the Syzygium zeylanicum L. extract can reduce the absorption of starch by oral inhibition of alpha-amylase, thereby further has weight loss effect.

10. The application of the Syzygium zeylanicum L. extract according to claim 2, wherein the oral dosage of the Syzygium zeylanicum L. extract is from 50 mg/kg to 200 mg/kg.

11. The application of the Syzygium zeylanicum L. extract according to claim 2, wherein the Syzygium zeylanicum L. extract is prepared as following steps:

Step 1;

grinding a portion of Syzygium zeylanicum L. at room temperature into a powder;

Step 2;

mixing the powder and a solvent at a ratio of 1;

10 by volume, and shaking at room temperature for 24 hours, and producing a mixture;

Step 3;

filtering the mixture of the step 2, and producing a residue and an extract;

Step 4;

mixing the residue of the step 3 and the solvent of the step 2 by 20 times volume of the powder of the step 1, and then shaking at room temperature for 24 hours;

Step 5;

repeat at least once of the steps 3 and 4, and collecting the extract;

Step 6;

vacuum drying the extract at 60°

C. to obtain Syzygium zeylanicum L. extract and storing at −

30°

C.

12. The application of the Syzygium zeylanicum L. extract according to claim 3, wherein the oral dosage of the Syzygium zeylanicum L. extract is from 50 mg/kg to 200 mg/kg.