Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals

• US 6,797,289 B2
• Filed: 07/11/2002
• Issued: 09/28/2004
• Est. Priority Date: 02/13/1998
• Status: Expired due to Term

• Current Assignee: Nutramax Laboratories Incorporated
• Original Assignee: Nutramax Laboratories Incorporated
• Inventors: Henderson, Robert, Henderson, Todd R., Hammad, Tarek, Soliman, Medhat, Corson, Barbara
• Primary Examiner(s): Wang, Shengjun
• Application Number:
  US10/192,318
• Publication Number:
  US 20030129261A1
• Time in Patent Office: 810 Days
• Field of Search: 514/62, 514/23, 514/42, 424/757
• US Class Current: 424/757
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 38/446 Superoxide dismutase (1.15)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Claims

1. A composition for the treatment, repair or prevention of damage to connective tissue comprising:

a synergistic combination of an aminosugar and avocado/soybean unsaponifiables.

2. The composition of claim 1, wherein the aminosugar is selected from the group consisting of glucosamine, glucosamine salts, and mixtures thereof.

3. The composition of claim 2, wherein the glucosamine salt is selected from the group consisting of glucosamine hydrochloride, glucosamine sulfate, N-acetylglucosamine and salts thereof.

4. The composition of claim 1, wherein the synergistic combination is administered orally, sublingually, nasally, gutturally, rectally, transdermally, or parenterally.