Branched polymers and their conjugates

  • US 7,026,440 B2
  • Filed: 11/07/2002
  • Issued: 04/11/2006
  • Est. Priority Date: 11/07/2001
  • Status: Active Grant
First Claim
Patent Images

1. A branched reactive polymer having the structure:


  • Y—

    (X)p-R(—

    X′

    -POLY)qwherein;

    R is an aliphatic hydrocarbon having a length of at least three carbon atoms;

    each POLY is a water soluble and non-peptide polymer, wherein the molecular weight of each POLY is selected such that the total molecular weight or the branched reactive polymer is independently selected from the group consisting of poly(alkylene glycol), poly(oxyethylated polyol), poly(olefinic alcohol), poly(vinylpyrrolidone), poly(hydroxyalkylmethacrylamide), poly(hydroxyalkylmethacrylate), polysaccharides, poly(α

    -hydroxy acid), poly(vinyl alcohol), plyphosphazene, polyoxazoline, poly(N-acryloylmorpholine), and copolymers, terpolymers, and mixtures thereof is at least about 5,000 Da;

    X′

    is a heteroatom linkage;

    X is a linker;

    p is 0 or 1;

    q is 2 to about 10; and

    Y is a functional group reactive with an electrophilic or nucleophilic group.

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