Handheld raman blood analyzer
First Claim
1. An apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
- a port sized and configured for receiving a test strip comprising a sample of blood on a target region of the test strip;
a light source for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation;
a low resolution diffraction grating dispersion element positioned to receive and separate the scattered radiation into different wavelength components;
a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and
a processor for processing data from the detector array and calculating information about an analyte within the blood sample,wherein the low resolution diffraction grating dispersion element provides the apparatus with a resolution in the range of 10 cm−
1 to 100 cm−
1.
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Accused Products
Abstract
Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the blood sample.
147 Citations
24 Claims
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1. An apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
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a port sized and configured for receiving a test strip comprising a sample of blood on a target region of the test strip; a light source for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation; a low resolution diffraction grating dispersion element positioned to receive and separate the scattered radiation into different wavelength components; a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and a processor for processing data from the detector array and calculating information about an analyte within the blood sample, wherein the low resolution diffraction grating dispersion element provides the apparatus with a resolution in the range of 10 cm−
1 to 100 cm−
1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 21, 22)
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16. An apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
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a strip for receiving a sample of blood on a target region, the target region including a material to provide surface enhanced Raman scattering; a laser for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation; a low resolution diffraction grating dispersion element positioned to receive and separate the scattered radiation into different wavelength components; a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and a processor for processing data from the detector array and calculating glucose concentration and information about at least one other analyte within the blood sample, wherein the low resolution diffraction grating dispersion element provides the apparatus with a resolution in the range of 10 cm−
1 to 100 cm−
1. - View Dependent Claims (23)
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20. A method for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
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providing a disposable strip for receiving a sample of blood on a target region;
depositing a sample of blood on the target region of the disposable strip;irradiating the target region with a laser to produce a Raman spectrum consisting of scattered electromagnetic radiation; receiving and separating the scattered radiation into different wavelength components using a low resolution diffraction grating dispersion element providing a resolution in the range of 10 cm−
1 to 100 cm−
1;detecting at least some of the wavelength components of the scattered light using a detection array; processing data from the detector array and calculating information about an analyte within the blood sample with a processor; and displaying information related to the analyte detected within the blood sample on a screen. - View Dependent Claims (24)
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Specification