Transcutaneous analyte sensor
First Claim
Patent Images
1. A device for monitoring glucose concentration in a host, the device comprising:
- a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host;
an integrated receiver configured to receive the sensor data from the substantially continuous glucose sensor, wherein the integrated receiver comprises;
an in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample;
a processor module; and
a computer readable memory comprising;
instructions configured to cause the processor module to calibrate the sensor data received from the substantially continuous glucose sensor;
instructions configured to cause the processor module to determine a rate of change of the calibrated sensor data, to determine whether the rate of change is within a range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans, and to not allow the processor module to calibrate the sensor data when the rate of change is outside the range;
instructions configured to cause the processor module to estimate at least one projected glucose concentration value based at least in part on a linear extrapolation of calibrated sensor data and on a variation analysis; and
instructions configured to cause the processor module to activate an alarm when the projected glucose concentration value is greater than a high threshold value or less than a low threshold value.
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Reexamination
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. In some embodiments, a device is provided for monitoring glucose concentration in a host, including a continuous glucose sensor and an integrated receiver including a single point glucose monitor. In some embodiments, a computer system is provided that determines a rate of change of continuous analyte sensor data.
900 Citations
89 Claims
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1. A device for monitoring glucose concentration in a host, the device comprising:
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a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; an integrated receiver configured to receive the sensor data from the substantially continuous glucose sensor, wherein the integrated receiver comprises; an in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample; a processor module; and a computer readable memory comprising; instructions configured to cause the processor module to calibrate the sensor data received from the substantially continuous glucose sensor; instructions configured to cause the processor module to determine a rate of change of the calibrated sensor data, to determine whether the rate of change is within a range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans, and to not allow the processor module to calibrate the sensor data when the rate of change is outside the range; instructions configured to cause the processor module to estimate at least one projected glucose concentration value based at least in part on a linear extrapolation of calibrated sensor data and on a variation analysis; and instructions configured to cause the processor module to activate an alarm when the projected glucose concentration value is greater than a high threshold value or less than a low threshold value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A device for monitoring glucose concentration in a host, the device comprising:
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a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; an integrated receiver configured to receive the sensor data from the substantially continuous glucose sensor, wherein the integrated receiver comprises; an in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample; a processor module; and a computer readable memory comprising; instructions configured to cause the processor module to calibrate the sensor data received from the substantially continuous glucose sensor during normal physiological rates of change; instructions configured to cause the processor module to determine a rate of change of the calibrated sensor data; instructions configured to cause the processor module to not calibrate the sensor data using the glucose concentration measured by the single point glucose monitor when the rate of change of the calibrated sensor data is greater than about +/−
4 mg/dL/min;instructions configured to cause the processor module to estimate at least one projected glucose concentration value based at least in part on a linear extrapolation of calibrated sensor data and on a variation analysis; and instruction configured to cause the processor module to activate an alarm when the projected glucose concentration value is greater than a high threshold value or less than a low threshold value. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A device for monitoring glucose concentration in a host, the device comprising:
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a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; an integrated receiver configured to receive the sensor data from the substantially continuous glucose sensor, wherein the integrated receiver comprises; an in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample; a processor module; and a computer readable memory comprising; instructions configured to cause the processor module to calibrate the sensor data received from the substantially continuous glucose sensor; instructions configured to cause the processor module to determine a rate of change of the calibrated sensor data, to determine whether the rate of change is within a range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans, and to not allow the processor module to calibrate the sensor data when the rate of change is outside the range; and instructions configured to cause a simultaneous display of a first output for the calibrated sensor data and a second output for the glucose concentration measured by the single point glucose monitor. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A device for monitoring glucose concentration in a host, the device comprising:
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a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; an integrated receiver configured to receive the sensor data from the substantially continuous glucose sensor, wherein the integrated receiver comprises; an in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample; a processor module; and a computer readable memory comprising; instructions configured to cause the processor module to calibrate the sensor data received from the substantially continuous glucose sensor during normal physiological rates of change; instructions configured to cause the processor module to determine a rate of change of the calibrated sensor data; instructions configured to cause the processor module to not calibrate the sensor data using the glucose concentration measured by the single point glucose monitor when the rate of change of the calibrated sensor data is greater than about +/−
4 mg/dL/min; andinstructions configured to cause a simultaneous display of a first output for the calibrated sensor data and a second output for the glucose concentration measured by the single point glucose monitor. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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Specification