Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
First Claim
1. An internal medical device comprising:
- (a) electrodes that are adapted to be positioned in a lumen of the cardiovascular system that is created by surrounding tissue upon implantation or insertion of said medical device in a subject, said electrodes further being adapted to have said surrounding tissue positioned between them upon deployment of said medical device within said lumen, (b) a power source adapted to apply a voltage across said electrodes, thereby generating an electric field having a vector that is directed into said surrounding tissue, and (c) a therapeutic agent source adapted to introduce a therapeutic agent into said electric field, wherein said device comprises an expandable tubular medical device substrate, wherein said therapeutic agent source comprises a charged therapeutic agent dispersed within an ion-conductive polymeric coating region disposed over said substrate, and wherein said electrodes comprise a first electrode provided beneath and in electrical contact with the polymeric coating region and a tissue penetrating electrode which penetrates said surrounding tissue upon deployment of said device by expansion of said substrate.
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Accused Products
Abstract
The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
56 Citations
42 Claims
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1. An internal medical device comprising:
- (a) electrodes that are adapted to be positioned in a lumen of the cardiovascular system that is created by surrounding tissue upon implantation or insertion of said medical device in a subject, said electrodes further being adapted to have said surrounding tissue positioned between them upon deployment of said medical device within said lumen, (b) a power source adapted to apply a voltage across said electrodes, thereby generating an electric field having a vector that is directed into said surrounding tissue, and (c) a therapeutic agent source adapted to introduce a therapeutic agent into said electric field, wherein said device comprises an expandable tubular medical device substrate, wherein said therapeutic agent source comprises a charged therapeutic agent dispersed within an ion-conductive polymeric coating region disposed over said substrate, and wherein said electrodes comprise a first electrode provided beneath and in electrical contact with the polymeric coating region and a tissue penetrating electrode which penetrates said surrounding tissue upon deployment of said device by expansion of said substrate.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
Specification