Modified G-CSF polypeptide

  • US 8,058,398 B2
  • Filed: 04/25/2005
  • Issued: 11/15/2011
  • Est. Priority Date: 01/28/1993
  • Status: Expired due to Fees
First Claim
Patent Images

1. A modified G-CSF polypeptide comprising the amino acid sequence shown in SEQ ID NO:

  • 2 anda first chemical moiety attached directly to an external loop;

    a second chemical moiety attached to the first chemical moiety;

    wherein the first chemical moiety is a polysaccharide and the second chemical moiety is polyethelene glycol;

    wherein the modified G-CSF polypeptide has ability to selectively stimulate the production of neutrophils; and

    wherein the N terminal methionine as set forth in SEQ ID NO;

    2 is optional.

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