Systems and methods for status indication in a single-use biomedical and bioprocess system

• US 9,571,904 B2
• Filed: 11/21/2013
• Issued: 02/14/2017
• Est. Priority Date: 11/21/2013
• Status: Active Grant

• Current Assignee: Cytiva Sweden AB (Danaher Corporation)
• Original Assignee: GE Healthcare Bio-Sciences AB (General Electric Company)
• Inventors: Potyrailo, Radislav A., Gebauer, Klaus, Stridsberg-Friden, Kajsa, Wortley, Timothy A.
• Primary Examiner(s): ALAM, MIRZA F
• Application Number:
  US14/086,117
• Publication Number:
  US 20150137992A1
• Time in Patent Office: 1,181 Days
• Field of Search: 340/870.01, 340/10.1, 340/572.7, 340/572.1, 340/572.8, 340/10.3, 340/10.52, 204/401, 204/403.1, 438/3, 438/57
• US Class Current: 1/1
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: C12M 41/48 Automatic or computerized control automatic analysis G01N35/00
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G06K 19/0702 the arrangement including a battery
• CPC Class Codes: G06K 19/0707 the arrangement being capable of collecting energy from external energy sources, e.g. thermocouples, vibration, electromagnetic radiation G06K19/0702 takes precedence
• CPC Class Codes: G06K 19/07745 Mounting details of integrated circuit chips
• CPC Class Codes: G08B 21/18 Status alarms G08B21/02 takes precedence
• CPC Class Codes: H04Q 2209/30 using a wired architecture
• CPC Class Codes: H04Q 2209/47 using RFID associated with sensors
• CPC Class Codes: H04Q 9/00 Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom

Abstract

Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioproces sing platform including the component.

Claims

1. A disposable bioprocessing component comprising:

a sensor comprising;

a first portion attached at a predetermined position adjacent to the disposable bioprocessing component to detect a position and an operational state of the disposable bioproces sing component, and comprising a radio frequency identification (RFID) tag and configured to provide an identifier and a status indication based on the position and the operational state of the disposable bioprocessing component in real-time when activated; and

a second portion separate from the first portion, and removably affixed to another component physically separated and spaced apart from the disposable bioprocessing component, and comprising a wireless sensor node and configured to;

(i) supply power to and activate the first portion to transmit the status indication and the identifier, and (ii) provide network connectivity, only when the second portion is brought within a predetermined physical proximity of the first portion, wherein the identifier and status indication are transmitted for use by a control system for a bioprocessing platform to execute an action at the disposable bioprocessing component.

2. The component of claim 1, wherein the component comprises at least one of a clamp, valve, actuator, switch, connector, and lever.

3. The component of claim 1, wherein the status indication comprises at least one of a position, a level, and an indication of an open or closed state of the component.

4. The component of claim 1, wherein the sensor is removably mounted on the component.

5. The component of claim 1, wherein at least one of the first and second portions of the sensor is integrated in the component.

6. The component of claim 1, wherein the control system is to prompt an action based on the transmitted identifier and status indication, the action comprising at least one of a confirmation, an alert, an alarm, a recording, an instruction to change configuration of the component, and a change in operation of the control system.

7. The component of claim 1, wherein the RFID tag comprises a sterilizable RFID tag.

8. The component of claim 7, wherein sterilization is to be achieved by at least one of gamma irradiation, autoclaving, steam, electron beam, and gas.

9. The component of claim 1, wherein the RFID tag comprises at least one of a high frequency (HF) RFID tag, a low frequency (LF) RFID tag, and a near field communication (NFC) RFID tag.

10. The component of claim 1, wherein at least one of the first and second portions of the sensor comprises a barcode associated with an optical reader.

11. A sensor device for a disposable bioprocessing component, the sensor device comprising:

a first portion affixed at a predetermined position adjacent to the component to detect a position and an operational state of the disposable bioprocessing component, and comprising a radio frequency identification (RFID) tag and configured to provide an identifier an a status indication based on the position and the operational state of the disposable processing component in real-time when activated; and

a second portion separate from the first portion, and removably affixed to another component physically separated and spaced apart from the disposable bioprocessing component, and comprising a wireless sensor node and configured to;

(i) supply power and activate the first portion to transmit the status indication and the identifier, and (ii) provide network connectivity, only when the second portion is brought within a predetermined physical proximity of the first portion, wherein the sensor device configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component, to execute an action at the disposable bioprocessing component.

12. The device of claim 10, wherein the component comprises at least one of a clamp, valve, actuator, switch, connector, and lever.

13. The device of claim 10, wherein the status indication comprises at least one of a position, a level, and an indication of an open or closed state of the component.

14. The device of claim 10, wherein the sensor is removably mounted on the component.

15. The device of claim 10, wherein at least one of the first and second portions of the sensor is integrated in the component.

16. The device of claim 10, wherein the control computer is to prompt an action based on the transmitted identifier and status indication, the action comprising at least one of an alert, an alarm, a recording, an instruction to change configuration of the component, and a change in operation of the bioprocessing platform.

17. The device of claim 10, wherein at least one of the first and second portions of the sensor comprises a barcode associated with an optical reader.

18. A method to monitor a component in a bioprocessing system including a bioprocessing subsystem and a control subsystem, said method comprising:

attaching a first portion of a sensor at a predetermined position adjacent to the component to detect a position and an operational state of the component, the first portion comprising a radio frequency identification (RFID) tag;

identifying and providing a status indication in real-time, via the RFID tag based on the position and the operational state of the component based on feedback from the first portion of the sensor associated with the component when activated;

supplying power to and activating the first portion, by a second portion separate from the first portion and removably affixed to another component physically separated and spaced apart from the component, and comprising a wireless sensor node, to transmit the status indication and the identifier, and providing network connectivity, only when the second portion is brought within a predetermined physical proximity of the first portion;

transmitting the identifier and status indication for use by the control subsystem for a bioproces sing system; and

facilitating triggering of an action via the control subsystem, at the component based on the transmitted identifier and status indication.

19. A method of process control by monitoring a component in a bioproces sing system, said method comprising:

attaching a first portion of a sensor at a predetermined position adjacent to the component to detect a position and an operational state of the component, the first portion comprising a radio frequency identification (RFID) tag;

identifying and providing a status indication in real-time, via the RFID tag based on the position and the operational state of the component based on feedback from a first portion of a sensor associated with the component when activated;

monitoring the process to identify a user action;

supplying power to and activating the first portion, by a second portion separate from the first portion and removably affixed to another component physically separated and spaced apart from the component, and comprising a wireless sensor node, to transmit the status indication and the identifier and provide network connectivity, only when the second portion is brought within a predetermined physical proximity of the first portion;

transmitting the identifier and status indication for use by the a control system for a bioproces sing system; and

facilitating triggering of an action via the control system, at the component based on the transmitted identifier and status indication.