Localized temperature control for spatial arrays of reaction media

  • US 9,623,414 B2
  • Filed: 12/11/2014
  • Issued: 04/18/2017
  • Est. Priority Date: 05/23/2003
  • Status: Active Grant
First Claim
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1. Apparatus for performing polymerase chain reactions in a plurality of samples, said apparatus comprising:

  • a plurality of thermally conductive sample blocks for polymerase chain reactions, arranged in a fixed horizontal array, wherein each sample block comprises a plurality of sample wells and is configured to retain a plurality of samples;

    a plurality of independently controlled thermoelectric modules, a thermoelectric module positioned underneath each said sample block, wherein the thermoelectric modules are configured to cycle the temperatures of the sample blocks for polymerase chain reactions;

    a layer of thermally conductive material between each sample block and each thermoelectric module; and

    a solid barrier of thermally insulating material positioned between each pair of adjacent sample blocks to thermally isolate the sample blocks of the pair from each other.

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